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==KSHV uracil-DNA glycosylase, apo form==
==KSHV uracil-DNA glycosylase, apo form==
<StructureSection load='5nn7' size='340' side='right' caption='[[5nn7]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='5nn7' size='340' side='right'caption='[[5nn7]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5nn7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Hhv-8 Hhv-8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NN7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NN7 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5nn7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_gammaherpesvirus_8 Human gammaherpesvirus 8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NN7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5NN7 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5nnu|5nnu]], [[5nnh|5nnh]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ORF46 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=37296 HHV-8])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5nn7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nn7 OCA], [https://pdbe.org/5nn7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5nn7 RCSB], [https://www.ebi.ac.uk/pdbsum/5nn7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5nn7 ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Uracil-DNA_glycosylase Uracil-DNA glycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.27 3.2.2.27] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nn7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nn7 OCA], [http://pdbe.org/5nn7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nn7 RCSB], [http://www.ebi.ac.uk/pdbsum/5nn7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nn7 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/Q76RG8_HHV8 Q76RG8_HHV8]] Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or deamination of cytosines. Therefore may reduce deleterious uracil incorporation into the viral genome, particularly in terminally differentiated cells which lack DNA repair enzymes.[HAMAP-Rule:MF_04046]  
[https://www.uniprot.org/uniprot/UNG_HHV8P UNG_HHV8P] Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or deamination of cytosines. Therefore may reduce deleterious uracil incorporation into the viral genome, particularly in terminally differentiated cells which lack DNA repair enzymes.[HAMAP-Rule:MF_04046]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5nn7" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5nn7" style="background-color:#fffaf0;"></div>
==See Also==
*[[DNA glycosylase 3D structures|DNA glycosylase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Hhv-8]]
[[Category: Human gammaherpesvirus 8]]
[[Category: Uracil-DNA glycosylase]]
[[Category: Large Structures]]
[[Category: Bagneris, C]]
[[Category: Bagneris C]]
[[Category: Barrett, T]]
[[Category: Barrett T]]
[[Category: Cole, A R]]
[[Category: Cole AR]]
[[Category: Earl, C]]
[[Category: Earl C]]
[[Category: Savva, R]]
[[Category: Savva R]]
[[Category: Hydrolase]]
[[Category: Uracil-dna glycosylase]]
Retrieved from "https://proteopedia.org/5nn7"