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[[Image:2gsh.gif|left|200px]]


{{Structure
==Crystal structure of L-rhamnonate dehydratase from Salmonella typhimurium==
|PDB= 2gsh |SIZE=350|CAPTION= <scene name='initialview01'>2gsh</scene>, resolution 2.393&Aring;
<StructureSection load='2gsh' size='340' side='right'caption='[[2gsh]], [[Resolution|resolution]] 2.39&Aring;' scene=''>
|SITE=
== Structural highlights ==
|LIGAND= <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
<table><tr><td colspan='2'>[[2gsh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium_str._LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GSH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GSH FirstGlance]. <br>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/L-rhamnonate_dehydratase L-rhamnonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.90 4.2.1.90] </span>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.393&#8491;</td></tr>
|GENE= STM2291 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=602 Salmonella typhimurium])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4948 COG4948], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03327 MR_like_2]</span>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gsh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gsh OCA], [https://pdbe.org/2gsh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gsh RCSB], [https://www.ebi.ac.uk/pdbsum/2gsh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gsh ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/2gsh TOPSAN]</span></td></tr>
|RELATEDENTRY=
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gsh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gsh OCA], [http://www.ebi.ac.uk/pdbsum/2gsh PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2gsh RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/RHMD_SALTY RHMD_SALTY] Catalyzes the dehydration of L-rhamnonate to 2-keto-3-deoxy-L-rhamnonate (KDR). Can also dehydrate L-lyxonate and L-mannonate, although less efficiently, but not 2-keto-4-hydroxyheptane-1,7-dioate.<ref>PMID:18754693</ref>
 
== Evolutionary Conservation ==
'''Crystal structure of L-rhamnonate dehydratase from Salmonella typhimurium'''
[[Image:Consurf_key_small.gif|200px|right]]
 
Check<jmol>
 
  <jmolCheckbox>
==About this Structure==
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gs/2gsh_consurf.spt"</scriptWhenChecked>
2GSH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Salmonella_typhimurium Salmonella typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GSH OCA].  
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
[[Category: L-rhamnonate dehydratase]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: Salmonella typhimurium]]
  </jmolCheckbox>
[[Category: Single protein]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gsh ConSurf].
[[Category: Adams, J M.]]
<div style="clear:both"></div>
[[Category: Almo, S C.]]
== References ==
[[Category: Burley, S K.]]
<references/>
[[Category: Dickey, M.]]
__TOC__
[[Category: Gerlt, J.]]
</StructureSection>
[[Category: Malashkevich, V N.]]
[[Category: Large Structures]]
[[Category: NYSGXRC, New York Structural GenomiX Research Consortium.]]
[[Category: Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]]
[[Category: Patskovsky, Y.]]
[[Category: Adams JM]]
[[Category: Sauder, J M.]]
[[Category: Almo SC]]
[[Category: Wasserman, S R.]]
[[Category: Burley SK]]
[[Category: enolase]]
[[Category: Dickey M]]
[[Category: new york structural genomix research consortium]]
[[Category: Gerlt J]]
[[Category: nysgxrc]]
[[Category: Malashkevich VN]]
[[Category: protein structure initiative]]
[[Category: Patskovsky Y]]
[[Category: psi]]
[[Category: Sauder JM]]
[[Category: structural genomic]]
[[Category: Wasserman SR]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:20:54 2008''

Latest revision as of 09:46, 30 August 2023

Crystal structure of L-rhamnonate dehydratase from Salmonella typhimurium

2gsh, resolution 2.39Å

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