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==Evidence for domain-specific recognition of SK and Kv channels by MTX and HsTx1 scorpion toxins==
==Evidence for domain-specific recognition of SK and Kv channels by MTX and HsTx1 scorpion toxins==
<StructureSection load='1wpd' size='340' side='right' caption='[[1wpd]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='1wpd' size='340' side='right'caption='[[1wpd]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1wpd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Scorpio_maurus_palmatus,_heterometrus_spinifer Scorpio maurus palmatus, heterometrus spinifer]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WPD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WPD FirstGlance]. <br>
<table><tr><td colspan='2'>[[1wpd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Heterometrus_spinifer Heterometrus spinifer] and [https://en.wikipedia.org/wiki/Scorpio_palmatus Scorpio palmatus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WPD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WPD FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wpd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wpd OCA], [http://pdbe.org/1wpd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wpd RCSB], [http://www.ebi.ac.uk/pdbsum/1wpd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1wpd ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wpd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wpd OCA], [https://pdbe.org/1wpd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wpd RCSB], [https://www.ebi.ac.uk/pdbsum/1wpd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wpd ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/KAX62_SCOMA KAX62_SCOMA]] Blocks voltage-gated potassium channels (Shaker B, and Kv1.2/KCNA2 (IC(50)=0.8 nM)) and is also active on Kv1.1/KCNA1 (IC(50)=45 nM) Kv1.3/KCNA3 (IC(50)=180 nM). Also inhibits apamin-sensitive small conductance calcium-activated potassium (SK/KCNN) channels, and inhibits intermediate conductance calcium-activated potassium (KCa3.1/KCNN4) channels.<ref>PMID:10920011</ref> <ref>PMID:12527813</ref> <ref>PMID:15498765</ref> <ref>PMID:9022673</ref> <ref>PMID:9136903</ref>
[https://www.uniprot.org/uniprot/KAX62_SCOPA KAX62_SCOPA] Blocks voltage-gated potassium channels Kv1.2/KCNA2 (IC(50)=0.12-0.8 nM), KCa3.1/KCNN4 (IC(50)=1-2.2 nM), Shaker B (IC(50)=2.39-80 nM), Kv1.1/KCNA1 (IC(50)=37-45 or no activity, depending on the study), Kv1.3/KCNA3 (IC(50)=150-180 or no activity, depending on the study).<ref>PMID:10888198</ref> <ref>PMID:10920011</ref> <ref>PMID:12527813</ref> <ref>PMID:15498765</ref> <ref>PMID:18042681</ref> <ref>PMID:9022673</ref> <ref>PMID:9136903</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Potassium channel toxin|Potassium channel toxin]]
*[[Potassium channel toxin 3D structures|Potassium channel toxin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Scorpio maurus palmatus, heterometrus spinifer]]
[[Category: Heterometrus spinifer]]
[[Category: Andreotti, N]]
[[Category: Large Structures]]
[[Category: Beeton, C]]
[[Category: Scorpio palmatus]]
[[Category: Chandy, G K]]
[[Category: Andreotti N]]
[[Category: Darbon, H]]
[[Category: Beeton C]]
[[Category: Ferrat, G]]
[[Category: Chandy GK]]
[[Category: Regaya, I]]
[[Category: Darbon H]]
[[Category: Sabatier, J M]]
[[Category: De Waard M]]
[[Category: Waard, M De]]
[[Category: Ferrat G]]
[[Category: Chimera]]
[[Category: Regaya I]]
[[Category: Neurotoxin]]
[[Category: Sabatier JM]]
[[Category: Toxin]]
Retrieved from "https://proteopedia.org/1wpd"