1wbu: Difference between revisions

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==Fragment based lead discovery using crystallography==
==Fragment based lead discovery using crystallography==
<StructureSection load='1wbu' size='340' side='right' caption='[[1wbu]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='1wbu' size='340' side='right'caption='[[1wbu]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1wbu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WBU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WBU FirstGlance]. <br>
<table><tr><td colspan='2'>[[1wbu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WBU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WBU FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=WBU:5-AMINO-1H-PYRIMIDINE-2,4-DIONE'>WBU</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=WBU:5-AMINO-1H-PYRIMIDINE-2,4-DIONE'>WBU</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wbu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wbu OCA], [http://pdbe.org/1wbu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wbu RCSB], [http://www.ebi.ac.uk/pdbsum/1wbu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1wbu ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wbu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wbu OCA], [https://pdbe.org/1wbu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wbu RCSB], [https://www.ebi.ac.uk/pdbsum/1wbu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wbu ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/RNAS1_BOVIN RNAS1_BOVIN]] Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single stranded and double stranded RNA.<ref>PMID:7479688</ref>
[https://www.uniprot.org/uniprot/RNAS1_BOVIN RNAS1_BOVIN] Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single stranded and double stranded RNA.<ref>PMID:7479688</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
*[[Ribonuclease|Ribonuclease]]
*[[Ribonuclease 3D structures|Ribonuclease 3D structures]]
*[[Temp|Temp]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Pancreatic ribonuclease]]
[[Category: Large Structures]]
[[Category: Cleasby, A]]
[[Category: Cleasby A]]
[[Category: Hartshorn, M J]]
[[Category: Hartshorn MJ]]
[[Category: Jhoti, H]]
[[Category: Jhoti H]]
[[Category: Murray, C W]]
[[Category: Murray CW]]
[[Category: Tickle, I J]]
[[Category: Tickle IJ]]
[[Category: Endonuclease]]
[[Category: Glycoprotein]]
[[Category: Hydrolase]]
[[Category: Inhibitor]]
[[Category: Ribonuclease]]
Retrieved from "https://proteopedia.org/1wbu"