3b5b: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,329,557 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,329,557 edits
No edit summary
 
(2 intermediate revisions by the same user not shown)
Line 1: Line 1:


==Crystal structure of the thymidylate synthase k48q==
==Crystal structure of the thymidylate synthase k48q==
<StructureSection load='3b5b' size='340' side='right' caption='[[3b5b]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
<StructureSection load='3b5b' size='340' side='right'caption='[[3b5b]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3b5b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecobb Ecobb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B5B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3B5B FirstGlance]. <br>
<table><tr><td colspan='2'>[[3b5b]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_BL21 Escherichia coli BL21]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B5B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3B5B FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=NDN:2-DEOXY-5-NITROURIDINE+5-(DIHYDROGEN+PHOSPHATE)'>NDN</scene>, <scene name='pdbligand=NDU:2-DEOXY-5-NITROURIDINE+5-MONOPHOSPHATE'>NDU</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">thyA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=511693 ECOBB])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=NDN:2-DEOXY-5-NITROURIDINE+5-(DIHYDROGEN+PHOSPHATE)'>NDN</scene>, <scene name='pdbligand=NDU:2-DEOXY-5-NITROURIDINE+5-MONOPHOSPHATE'>NDU</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3b5b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b5b OCA], [https://pdbe.org/3b5b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3b5b RCSB], [https://www.ebi.ac.uk/pdbsum/3b5b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3b5b ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3b5b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b5b OCA], [http://pdbe.org/3b5b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3b5b RCSB], [http://www.ebi.ac.uk/pdbsum/3b5b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3b5b ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TYSY_ECOLI TYSY_ECOLI]] Provides the sole de novo source of dTMP for DNA biosynthesis. This protein also binds to its mRNA thus repressing its own translation.  
[https://www.uniprot.org/uniprot/TYSY_ECOLI TYSY_ECOLI] Provides the sole de novo source of dTMP for DNA biosynthesis. This protein also binds to its mRNA thus repressing its own translation.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 32: Line 31:


==See Also==
==See Also==
*[[Thymidylate synthase|Thymidylate synthase]]
*[[Thymidylate synthase 3D structures|Thymidylate synthase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Ecobb]]
[[Category: Escherichia coli BL21]]
[[Category: Thymidylate synthase]]
[[Category: Large Structures]]
[[Category: Arreola, R]]
[[Category: Arreola R]]
[[Category: Maley, F]]
[[Category: Maley F]]
[[Category: Montfort, W R]]
[[Category: Montfort WR]]
[[Category: Sotelo-Mundo, R R]]
[[Category: Sotelo-Mundo RR]]
[[Category: 5-no2-dump]]
[[Category: Methyltransferase]]
[[Category: Nucleotide biosynthesis]]
[[Category: Repressor]]
[[Category: Rna-binding]]
[[Category: Substrate anologue]]
[[Category: Transferase]]
[[Category: Translation regulation]]
Retrieved from "https://proteopedia.org/3b5b"