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==STRUCTURE OF THE SARS-CORONAVIRUS ORF7A ACCESSORY PROTEIN==
==STRUCTURE OF THE SARS-CORONAVIRUS ORF7A ACCESSORY PROTEIN==
<StructureSection load='1xak' size='340' side='right' caption='[[1xak]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='1xak' size='340' side='right'caption='[[1xak]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1xak]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cvhsa Cvhsa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XAK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XAK FirstGlance]. <br>
<table><tr><td colspan='2'>[[1xak]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome-related_coronavirus Severe acute respiratory syndrome-related coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XAK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XAK FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xak FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xak OCA], [http://pdbe.org/1xak PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xak RCSB], [http://www.ebi.ac.uk/pdbsum/1xak PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1xak ProSAT], [http://www.topsan.org/Proteins/MCSG/1xak TOPSAN]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xak FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xak OCA], [https://pdbe.org/1xak PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xak RCSB], [https://www.ebi.ac.uk/pdbsum/1xak PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xak ProSAT], [https://www.topsan.org/Proteins/MCSG/1xak TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/NS7A_CVHSA NS7A_CVHSA]] Non-structural protein which is dispensable for virus replication in cell culture.<ref>PMID:15564512</ref>
[https://www.uniprot.org/uniprot/NS7A_SARS NS7A_SARS] Plays a role as antagonist of host tetherin (BST2), disrupting its antiviral effect. Acts by binding to BST2 thereby interfering with its glycosylation. May suppress small interfering RNA (siRNA). May bind to host ITGAL, thereby playing a role in attachment or modulation of leukocytes.<ref>PMID:15564512</ref> <ref>PMID:18020948</ref> <ref>PMID:20631126</ref> <ref>PMID:26378163</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Cvhsa]]
[[Category: Large Structures]]
[[Category: Fremont, D H]]
[[Category: Severe acute respiratory syndrome-related coronavirus]]
[[Category: Lee, C A]]
[[Category: Fremont DH]]
[[Category: Structural genomic]]
[[Category: Lee CA]]
[[Category: Nelson, C A]]
[[Category: Nelson CA]]
[[Category: Beta sandwich]]
[[Category: I-set ig domain]]
[[Category: Mcsg]]
[[Category: PSI, Protein structure initiative]]
[[Category: Viral protein]]
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