2h8g: Difference between revisions

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[[Image:2h8g.gif|left|200px]]


{{Structure
==5'-Methylthioadenosine Nucleosidase from Arabidopsis thaliana==
|PDB= 2h8g |SIZE=350|CAPTION= <scene name='initialview01'>2h8g</scene>, resolution 1.5&Aring;
<StructureSection load='2h8g' size='340' side='right'caption='[[2h8g]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=ADE:ADENINE'>ADE</scene>
<table><tr><td colspan='2'>[[2h8g]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H8G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2H8G FirstGlance]. <br>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Methylthioadenosine_nucleosidase Methylthioadenosine nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.16 3.2.2.16] </span>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
|GENE= AT4g38800 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 Arabidopsis thaliana])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADE:ADENINE'>ADE</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2h8g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h8g OCA], [https://pdbe.org/2h8g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2h8g RCSB], [https://www.ebi.ac.uk/pdbsum/2h8g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2h8g ProSAT]</span></td></tr>
|RELATEDENTRY=
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2h8g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h8g OCA], [http://www.ebi.ac.uk/pdbsum/2h8g PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2h8g RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/MTN1_ARATH MTN1_ARATH] Enzyme of the methionine cycle that catalyzes the irreversible cleavage of the glycosidic bond in 5'-methylthioadenosine (MTA) to adenine and 5'-methylthioribose. Contributes to the maintenance of AdoMet homeostasis and is required to sustain high rates of ethylene synthesis. Inactive towards S-adenosylhomocysteine (SAH/AdoHcy).<ref>PMID:17144895</ref> <ref>PMID:18342331</ref> <ref>PMID:20345605</ref>
 
== Evolutionary Conservation ==
'''5'-Methylthioadenosine Nucleosidase from Arabidopsis thaliana'''
[[Image:Consurf_key_small.gif|200px|right]]
 
Check<jmol>
 
  <jmolCheckbox>
==About this Structure==
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h8/2h8g_consurf.spt"</scriptWhenChecked>
2H8G is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H8G OCA].  
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 
    <text>to colour the structure by Evolutionary Conservation</text>
==Reference==
  </jmolCheckbox>
Crystal structure of 5'-methylthioadenosine nucleosidase from Arabidopsis thaliana at 1.5-A resolution., Park EY, Oh SI, Nam MJ, Shin JS, Kim KN, Song HK, Proteins. 2006 Nov 1;65(2):519-23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16909418 16909418]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2h8g ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Arabidopsis thaliana]]
[[Category: Arabidopsis thaliana]]
[[Category: Methylthioadenosine nucleosidase]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Kim KN]]
[[Category: Kim, K N.]]
[[Category: Nam MJ]]
[[Category: Nam, M J.]]
[[Category: Oh SI]]
[[Category: Oh, S I.]]
[[Category: Park EY]]
[[Category: Park, E Y.]]
[[Category: Shin JS]]
[[Category: Shin, J S.]]
[[Category: Song HK]]
[[Category: Song, H K.]]
[[Category: protein-adenine complex]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:26:56 2008''
Retrieved from "https://proteopedia.org/2h8g"