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[[Image:2he3.gif|left|200px]]


{{Structure
==Crystal structure of the selenocysteine to cysteine mutant of human glutathionine peroxidase 2 (GPX2)==
|PDB= 2he3 |SIZE=350|CAPTION= <scene name='initialview01'>2he3</scene>, resolution 2.10&Aring;
<StructureSection load='2he3' size='340' side='right'caption='[[2he3]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>
<table><tr><td colspan='2'>[[2he3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HE3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HE3 FirstGlance]. <br>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_peroxidase Glutathione peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.9 1.11.1.9] </span>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
|GENE= GPX2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2he3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2he3 OCA], [https://pdbe.org/2he3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2he3 RCSB], [https://www.ebi.ac.uk/pdbsum/2he3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2he3 ProSAT]</span></td></tr>
|RELATEDENTRY=
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2he3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2he3 OCA], [http://www.ebi.ac.uk/pdbsum/2he3 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2he3 RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/GPX2_HUMAN GPX2_HUMAN] Could play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides. Tert-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydroperoxide but not phosphatidycholine hydroperoxide, can act as acceptors.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/he/2he3_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2he3 ConSurf].
<div style="clear:both"></div>


'''Crystal structure of the selenocysteine to cysteine mutant of human glutathionine peroxidase 2 (GPX2)'''
==See Also==
 
*[[Glutathione peroxidase|Glutathione peroxidase]]
 
__TOC__
==About this Structure==
</StructureSection>
2HE3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HE3 OCA].
[[Category: Glutathione peroxidase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C.]]
[[Category: Arrowsmith C]]
[[Category: Delft, F Von.]]
[[Category: Edwards A]]
[[Category: Edwards, A.]]
[[Category: Gileadi O]]
[[Category: Gileadi, O.]]
[[Category: Johansson C]]
[[Category: Johansson, C.]]
[[Category: Kavanagh KL]]
[[Category: Kavanagh, K L.]]
[[Category: Oppermann U]]
[[Category: Oppermann, U.]]
[[Category: Rojkova A]]
[[Category: Rojkova, A.]]
[[Category: Sundstrom M]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Weigelt J]]
[[Category: Sundstrom, M.]]
[[Category: Von Delft F]]
[[Category: Weigelt, J.]]
[[Category: gastrointestinal glutathione peroxidase 2]]
[[Category: gprp]]
[[Category: gshpx-gi]]
[[Category: sgc]]
[[Category: structural genomic]]
[[Category: structural genomics consortium]]
[[Category: thioredoxin fold]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:29:04 2008''

Latest revision as of 09:56, 30 August 2023

Crystal structure of the selenocysteine to cysteine mutant of human glutathionine peroxidase 2 (GPX2)

2he3, resolution 2.10Å

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