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==Staphylopine dehydrogenase (SaODH) - Apo==
==Staphylopine dehydrogenase (SaODH) - Apo==
<StructureSection load='6c4r' size='340' side='right' caption='[[6c4r]], [[Resolution|resolution]] 2.29&Aring;' scene=''>
<StructureSection load='6c4r' size='340' side='right'caption='[[6c4r]], [[Resolution|resolution]] 2.29&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6c4r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C4R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6C4R FirstGlance]. <br>
<table><tr><td colspan='2'>[[6c4r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C4R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6C4R FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.288&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AB466_12420, AB526_12775, AFP37_00945, APW47_05390 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6c4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c4r OCA], [http://pdbe.org/6c4r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6c4r RCSB], [http://www.ebi.ac.uk/pdbsum/6c4r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6c4r ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6c4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c4r OCA], [https://pdbe.org/6c4r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6c4r RCSB], [https://www.ebi.ac.uk/pdbsum/6c4r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6c4r ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ODH_STAAM ODH_STAAM] Catalyzes the NADPH-dependent reductive condensation of pyruvate to the intermediate formed by the adjacently encoded enzyme CntL, namely (2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate, leading to the production of staphylopine. This is the last step in the biosynthesis of the metallophore staphylopine, which is involved in the acquisition of nickel, cobalt, zinc, copper, and iron, and thus enables bacterial growth inside the host, where metal access is limited. Therefore, this enzyme probably contributes to staphylococcal virulence. Can use neither NADH nor alpha-ketoglutarate in place of NADPH and pyruvate, respectively.<ref>PMID:27230378</ref> <ref>PMID:29091735</ref> <ref>PMID:29618515</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Davis, C L]]
[[Category: Large Structures]]
[[Category: Lamb, A L]]
[[Category: Staphylococcus aureus]]
[[Category: McFarlane, J S]]
[[Category: Davis CL]]
[[Category: Opine dehydrogenase metallophore siderophore]]
[[Category: Lamb AL]]
[[Category: Oxidoreductase]]
[[Category: McFarlane JS]]
[[Category: Yersinopine pseudopaline staphylopine]]
Retrieved from "https://proteopedia.org/6c4r"