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==Crystal structure of the Lys-274 to Arg mutant of Candida tenuis xylose reductase (AKR2B5) bound to NAD+==
==Crystal structure of the Lys-274 to Arg mutant of Candida tenuis xylose reductase (AKR2B5) bound to NAD+==
<StructureSection load='1ye4' size='340' side='right' caption='[[1ye4]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='1ye4' size='340' side='right'caption='[[1ye4]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1ye4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_10573 Atcc 10573]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YE4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YE4 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1ye4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Yamadazyma_tenuis Yamadazyma tenuis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YE4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YE4 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ye6|1ye6]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">XYL1, XYLR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=45596 ATCC 10573])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ye4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ye4 OCA], [https://pdbe.org/1ye4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ye4 RCSB], [https://www.ebi.ac.uk/pdbsum/1ye4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ye4 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ye4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ye4 OCA], [http://pdbe.org/1ye4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ye4 RCSB], [http://www.ebi.ac.uk/pdbsum/1ye4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ye4 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/XYL1_CANTE XYL1_CANTE]] Reduces D-xylose into xylitol. Has a preference for NADPH, but can also utilize NADH as cosubstrate.  
[https://www.uniprot.org/uniprot/XYL1_CANTE XYL1_CANTE] Reduces D-xylose into xylitol. Has a preference for NADPH, but can also utilize NADH as cosubstrate.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Atcc 10573]]
[[Category: Large Structures]]
[[Category: Leitgeb, S]]
[[Category: Yamadazyma tenuis]]
[[Category: Nidetzky, B]]
[[Category: Leitgeb S]]
[[Category: Petschacher, B]]
[[Category: Nidetzky B]]
[[Category: Wilson, D K]]
[[Category: Petschacher B]]
[[Category: Beta-alpha-barrel akr aldo-keto reductase coenzyme specificity nad]]
[[Category: Wilson DK]]
[[Category: Oxidoreductase]]
Retrieved from "https://proteopedia.org/1ye4"