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[[Image:2hma.gif|left|200px]]


{{Structure
==The Crystal Structure of tRNA (5-Methylaminomethyl-2-Thiouridylate)-Methyltransferase TrmU from Streptococcus pneumoniae==
|PDB= 2hma |SIZE=350|CAPTION= <scene name='initialview01'>2hma</scene>, resolution 2.41&Aring;
<StructureSection load='2hma' size='340' side='right'caption='[[2hma]], [[Resolution|resolution]] 2.41&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>
<table><tr><td colspan='2'>[[2hma]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HMA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HMA FirstGlance]. <br>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/tRNA_(5-methylaminomethyl-2-thiouridylate)-methyltransferase tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.61 2.1.1.61] </span>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.41&#8491;</td></tr>
|GENE= trmU ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1313 Streptococcus pneumoniae])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=PRK00143 trmU], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01998 tRNA_Me_trans]</span>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hma FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hma OCA], [https://pdbe.org/2hma PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hma RCSB], [https://www.ebi.ac.uk/pdbsum/2hma PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hma ProSAT], [https://www.topsan.org/Proteins/MCSG/2hma TOPSAN]</span></td></tr>
|RELATEDENTRY=
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hma FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hma OCA], [http://www.ebi.ac.uk/pdbsum/2hma PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2hma RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/MNMA_STRPN MNMA_STRPN] Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
 
== Evolutionary Conservation ==
'''The Crystal Structure of tRNA (5-Methylaminomethyl-2-Thiouridylate)-Methyltransferase TrmU from Streptococcus pneumoniae'''
[[Image:Consurf_key_small.gif|200px|right]]
 
Check<jmol>
 
  <jmolCheckbox>
==About this Structure==
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hm/2hma_consurf.spt"</scriptWhenChecked>
2HMA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HMA OCA].  
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
[[Category: Single protein]]
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hma ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Streptococcus pneumoniae]]
[[Category: Streptococcus pneumoniae]]
[[Category: tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase]]
[[Category: Abdullah J]]
[[Category: Abdullah, J.]]
[[Category: Joachimiak A]]
[[Category: Joachimiak, A.]]
[[Category: Kim Y]]
[[Category: Kim, Y.]]
[[Category: Zhou M]]
[[Category: MCSG, Midwest Center for Structural Genomics.]]
[[Category: Zhou, M.]]
[[Category: alpha-beta]]
[[Category: beta barrel]]
[[Category: mcsg]]
[[Category: midwest center for structural genomic]]
[[Category: protein structure initiative]]
[[Category: psi-2]]
[[Category: structural genomic]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:32:17 2008''
Retrieved from "https://proteopedia.org/2hma"