6d79: Difference between revisions
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New page: '''Unreleased structure''' The entry 6d79 is ON HOLD Authors: Description: Category: Unreleased Structures |
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==Structure of CysZ, a sulfate permease from Pseudomonas Fragi== | |||
<StructureSection load='6d79' size='340' side='right'caption='[[6d79]], [[Resolution|resolution]] 3.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6d79]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_fragi_A22 Pseudomonas fragi A22]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D79 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6D79 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.501Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6d79 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d79 OCA], [https://pdbe.org/6d79 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6d79 RCSB], [https://www.ebi.ac.uk/pdbsum/6d79 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6d79 ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Sulfur, most abundantly found in the environment as sulfate (SO4(2-)), is an essential element in metabolites required by all living cells, including amino acids, co-factors and vitamins. However, current understanding of the cellular delivery of SO4(2-) at the molecular level is limited. CysZ has been described as a SO4(2-) permease, but its sequence family is without known structural precedent. Based on crystallographic structure information, SO4(2-) binding and flux experiments, we provide insight into the molecular mechanism of CysZ-mediated translocation of SO4(2-) across membranes. CysZ structures from three different bacterial species display a hitherto unknown fold and have subunits organized with inverted transmembrane topology. CysZ from Pseudomonas denitrificans assembles as a trimer of antiparallel dimers and the CysZ structures from two other species recapitulate dimers from this assembly. Mutational studies highlight the functional relevance of conserved CysZ residues. | |||
Structure-based analysis of CysZ-mediated cellular uptake of sulfate.,Assur Sanghai Z, Liu Q, Clarke OB, Belcher-Dufrisne M, Wiriyasermkul P, Giese MH, Leal-Pinto E, Kloss B, Tabuso S, Love J, Punta M, Banerjee S, Rajashankar KR, Rost B, Logothetis D, Quick M, Hendrickson WA, Mancia F Elife. 2018 May 24;7. pii: 27829. doi: 10.7554/eLife.27829. PMID:29792261<ref>PMID:29792261</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
<div class="pdbe-citations 6d79" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Pseudomonas fragi A22]] | |||
[[Category: Banerjee S]] | |||
[[Category: Clarke OB]] | |||
[[Category: Hendrickson WA]] | |||
[[Category: Liu Q]] | |||
[[Category: Mancia F]] | |||
[[Category: Rajashankar KR]] | |||
[[Category: Sanghai ZA]] | |||
Latest revision as of 07:53, 17 October 2024
Structure of CysZ, a sulfate permease from Pseudomonas Fragi
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