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==Crystal structure of the tandem PX-PH-domains of Bem3 from Saccharomyces cerevisiae==
==Crystal structure of the tandem PX-PH-domains of Bem3 from Saccharomyces cerevisiae==
<StructureSection load='6fsf' size='340' side='right' caption='[[6fsf]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='6fsf' size='340' side='right'caption='[[6fsf]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6fsf]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FSF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FSF FirstGlance]. <br>
<table><tr><td colspan='2'>[[6fsf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FSF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6FSF FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fsf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fsf OCA], [http://pdbe.org/6fsf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fsf RCSB], [http://www.ebi.ac.uk/pdbsum/6fsf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fsf ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6fsf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fsf OCA], [https://pdbe.org/6fsf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6fsf RCSB], [https://www.ebi.ac.uk/pdbsum/6fsf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6fsf ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/BEM3_YEAST BEM3_YEAST]] GTPase-activating protein (GAP) for CDC42 and less efficiently for RHO1. Negative regulator of the pheromone-response pathway through the STE20 protein kinase.<ref>PMID:8227021</ref> <ref>PMID:8300560</ref>
[https://www.uniprot.org/uniprot/BEM3_YEAST BEM3_YEAST] GTPase-activating protein (GAP) for CDC42 and less efficiently for RHO1. Negative regulator of the pheromone-response pathway through the STE20 protein kinase.<ref>PMID:8227021</ref> <ref>PMID:8300560</ref>  
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The structure of the tandem lipid-binding PX and pleckstrin-homology (PH) domains of the Cdc42 GTPase-activating protein Bem3 from Saccharomyces cerevisiae (strain S288c) has been determined to a resolution of 2.2 A (Rwork = 21.1%, Rfree = 23.4%). It shows that the domains adopt a relative orientation that enables them to simultaneously bind to a membrane and suggests possible cooperativity in membrane binding.
 
Structure of the tandem PX-PH domains of Bem3 from Saccharomyces cerevisiae.,Ali I, Eu S, Koch D, Bleimling N, Goody RS, Muller MP Acta Crystallogr F Struct Biol Commun. 2018 May 1;74(Pt 5):315-321. doi:, 10.1107/S2053230X18005915. Epub 2018 Apr 24. PMID:29718000<ref>PMID:29718000</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6fsf" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Ali, I]]
[[Category: Large Structures]]
[[Category: Bleimling, N]]
[[Category: Saccharomyces cerevisiae S288C]]
[[Category: Eu, S]]
[[Category: Ali I]]
[[Category: Goody, R S]]
[[Category: Bleimling N]]
[[Category: Koch, D]]
[[Category: Eu S]]
[[Category: Mueller, M P]]
[[Category: Goody RS]]
[[Category: Bem3]]
[[Category: Koch D]]
[[Category: Endocytosis]]
[[Category: Mueller MP]]
[[Category: Ph domain]]
[[Category: Phosphatidylinositol phosphate]]
[[Category: Phox]]
[[Category: Pip]]
[[Category: Pleckstrin homology]]
[[Category: Px domain]]
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