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[[Image:2hqp.jpg|left|200px]]


{{Structure
==Solution structure of L.casei dihydrofolate reductase complexed with NADPH, 32 structures==
|PDB= 2hqp |SIZE=350|CAPTION= <scene name='initialview01'>2hqp</scene>
<StructureSection load='2hqp' size='340' side='right'caption='[[2hqp]]' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>
<table><tr><td colspan='2'>[[2hqp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lacticaseibacillus_casei Lacticaseibacillus casei]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HQP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HQP FirstGlance]. <br>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
|GENE= folA, dhfR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1582 Lactobacillus casei])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hqp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hqp OCA], [https://pdbe.org/2hqp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hqp RCSB], [https://www.ebi.ac.uk/pdbsum/2hqp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hqp ProSAT]</span></td></tr>
|RELATEDENTRY=[[1lud|1LUD]], [[1yho|1YHO]], [[3dfr|3DFR]], [[2hm9|2HM9]]
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hqp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hqp OCA], [http://www.ebi.ac.uk/pdbsum/2hqp PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2hqp RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/DYR_LACCA DYR_LACCA] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hq/2hqp_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hqp ConSurf].
<div style="clear:both"></div>


'''Solution structure of L.casei dihydrofolate reductase complexed with NADPH, 32 structures'''
==See Also==
 
*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
2HQP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Lactobacillus_casei Lactobacillus casei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HQP OCA].
[[Category: Lacticaseibacillus casei]]
[[Category: Dihydrofolate reductase]]
[[Category: Large Structures]]
[[Category: Lactobacillus casei]]
[[Category: Birdsall B]]
[[Category: Single protein]]
[[Category: Polshakov VI]]
[[Category: Birdsall, B.]]
[[Category: Polshakov, V I.]]
[[Category: dhfr]]
[[Category: oxidoreductase]]
 
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Retrieved from "https://proteopedia.org/2hqp"