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==EXTENSION OF THE FOUR-STRANDED INTERCALATED CYTOSINE MOTIF BY ADENINE.ADENINE BASE PAIRING IN THE CRYSTAL STRUCTURE OF D(CCCAAT)==
==EXTENSION OF THE FOUR-STRANDED INTERCALATED CYTOSINE MOTIF BY ADENINE.ADENINE BASE PAIRING IN THE CRYSTAL STRUCTURE OF D(CCCAAT)==
<StructureSection load='241d' size='340' side='right' caption='[[241d]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
<StructureSection load='241d' size='340' side='right'caption='[[241d]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[241d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=241D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=241D FirstGlance]. <br>
<table><tr><td colspan='2'>[[241d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=241D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=241D FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=241d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=241d OCA], [http://pdbe.org/241d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=241d RCSB], [http://www.ebi.ac.uk/pdbsum/241d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=241d ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=241d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=241d OCA], [https://pdbe.org/241d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=241d RCSB], [https://www.ebi.ac.uk/pdbsum/241d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=241d ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The crystal structure of d(CCCAAT), refined at 2.0 A resolution, shows a four stranded molecule in which two parallel duplexes intercalate with opposite polarity, using cytosine.protonated cytosine base pairs. The intercalation motif in this structure is extended by adenine.adenine base pairs. Two topologically distinct broad grooves are found in the lath-like central part of the molecule with the phosphate groups on one side bent over towards each other, stabilized by bridging water molecules. At the 3' ends, two arrangements of intermolecular A.A.T base triplets are found, involving both asymmetric and symmetric A.A base pairs joined to thymine residues by Watson-Crick and reverse Hoogsteen base pairing, respectively.
Extension of the four-stranded intercalated cytosine motif by adenine.adenine base pairing in the crystal structure of d(CCCAAT).,Berger I, Kang C, Fredian A, Ratliff R, Moyzis R, Rich A Nat Struct Biol. 1995 May;2(5):416-25. PMID:7664099<ref>PMID:7664099</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 241d" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Berger, I]]
[[Category: Large Structures]]
[[Category: Fredian, A]]
[[Category: Berger I]]
[[Category: Kang, C]]
[[Category: Fredian A]]
[[Category: Moyzis, R]]
[[Category: Kang C]]
[[Category: Ratliff, R]]
[[Category: Moyzis R]]
[[Category: Rich, A]]
[[Category: Ratliff R]]
[[Category: Arallel-stranded tetraplex]]
[[Category: Rich A]]
[[Category: Base intercalated]]
[[Category: Dna]]
[[Category: Mismatched]]
[[Category: Quadruple helix]]
[[Category: U-dna]]

Latest revision as of 09:09, 14 February 2024

EXTENSION OF THE FOUR-STRANDED INTERCALATED CYTOSINE MOTIF BY ADENINE.ADENINE BASE PAIRING IN THE CRYSTAL STRUCTURE OF D(CCCAAT)

241d, resolution 1.85Å

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