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<scene name='77/778328/4h/1'>Text To Be Displayed</scene>{{Sandbox_Reserved_Telford2018}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE -->
<scene name='77/778328/4h/1'>Text To Be Displayed</scene>{{Sandbox_Reserved_Telford2018}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE -->
==Human Lactate Dehydrogenase (LDH)==
==Human Lactate Dehydrogenase==
<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>
<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>


Lactate dehydrogenase is an enzyme used for anaerobic respiration in humans. Anaerobic respiration is respiration without the involvement of oxygen. It is used during intense exercises or other strenuous activities, when one is lacking available oxygen. LDH is mainly found in the heart, liver, kidney, and muscles of the body; each with a slightly different composition. Lactate dehydrogenase is a quaternary structure found in humans. It has two main subunits, H and M (heart and muscle).Based on the different reactions the two subunits preform, different combinations can be found throughout the body. Lactate dehydrogenase is a main component of anaerobic respiration within the human body. This molecule come into play when there is a lack of oxygen, such as during intense exercise.  
Lactate dehydrogenase (LDH) is a main component of anaerobic respiration within the human body. This molecule come into play when there is a lack of oxygen, such as during intense exercise. Anaerobic respiration is defined as respiration without the involvement of oxygen. Anaerobic respiration is used during intense exercises or other strenuous activities, when one is lacking available oxygen. LDH is mainly found in the heart, liver, kidney, and muscles of the body; each with a slightly different composition. Lactate dehydrogenase is a quaternary structureis composed of two main subunits, H and M (heart and muscle).Based on the different reactions the two subunits preform, different combinations can be found throughout the body.  


== Structure ==
== Structure ==
Lactate dehydrogenase is a quaternary structure found in humans. It has two main subunits, H and M (heart and muscle). The H form converts pyruvates to lactate, while the M form converts lactate to pyruvates. Based on the different reactions the two subunits preform, different combinations can be found throughout the body. <scene name='77/778328/4h/1'>4H</scene> is found in the heart, <scene name='77/778328/3h1m/1'>3H1M</scene> is found in the reticuloendothelial (part of the immune system), 2H2M is found in the lungs, 1H3M is found in the kidneys, and 4M is found in the muscles and liver.
Lactate dehydrogenase is composed of quaternary structure and can be found in humans. It has two main subunits, H and M (heart and muscle). The H form converts pyruvate to lactate, while the M form converts lactate back to pyruvate. Based on the different reactions the two subunits preform, different combinations can be found throughout the body. <scene name='77/778328/4h/1'>4H</scene> is found in the heart, <scene name='77/778328/3h1m/1'>3H1M</scene> is found in the reticuloendothelial (part of the immune system), 2H2M is found in the lungs, 1H3M is found in the kidneys, and 4M is found in the muscles and liver.


== Function ==
== Function ==
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Lactate Dehydrogenase allows humans to perform strenuous exercises for a longer length of time. Without LDH, humans would not have an adequate amount of ATP to sucessfully perform intense exercises such as running, biking, etc. LDH allows our bodies to convert pyruvate into something that our body can utilize (lactate) to produce ATP when oxygen is unavailable.  
Lactate Dehydrogenase allows humans to perform strenuous exercises for a longer length of time. Without LDH, humans would not have an adequate amount of ATP to sucessfully perform intense exercises such as running, biking, etc. LDH allows our bodies to convert pyruvate into something that our body can utilize (lactate) to produce ATP when oxygen is unavailable.  


This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.


</StructureSection>
</StructureSection>
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Cook, W J, et al. “Biochemical and Structural Characterization of Cryptosporidium Parvum Lactate Dehydrogenase.” International Journal of Biological Macromolecules., U.S. National Library of Medicine, Mar. 2015, www.ncbi.nlm.nih.gov/pubmed/?term=25542170.
Cook, W J, et al. “Biochemical and Structural Characterization of Cryptosporidium Parvum Lactate Dehydrogenase.” International Journal of Biological Macromolecules., U.S. National Library of Medicine, Mar. 2015, www.ncbi.nlm.nih.gov/pubmed/?term=25542170.
Kavanagh, et al. “Structure of Toxoplasma Gondii LDH1: Active-Site Differences from Human Lactate Dehydrogenases and the Structural Basis for Efficient APAD+ Use.” Biochemistry, www.rcsb.org/structure/1PZE.


Kavanagh, et al. “Structure of Apo and Ternary Forms of Toxoplasma Gondii LDH2.” TO BE PUBLISHED, www.rcsb.org/structure/1SOV.
Kavanagh, et al. “Structure of Apo and Ternary Forms of Toxoplasma Gondii LDH2.” TO BE PUBLISHED, www.rcsb.org/structure/1SOV.


https://www.rcsb.org/structure/4nd4
Kavanagh, et al. “Structure of Toxoplasma Gondii LDH1: Active-Site Differences from Human Lactate Dehydrogenases and the Structural Basis for Efficient APAD+ Use.” Biochemistry, www.rcsb.org/structure/1PZE.
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