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==Crystal structure of paFAN1 bound to 2nt 5'flap DNA with gap with Manganese==
==Crystal structure of paFAN1 bound to 2nt 5'flap DNA with gap with Manganese==
<StructureSection load='5z6w' size='340' side='right' caption='[[5z6w]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
<StructureSection load='5z6w' size='340' side='right'caption='[[5z6w]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5z6w]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Z6W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Z6W FirstGlance]. <br>
<table><tr><td colspan='2'>[[5z6w]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Z6W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5Z6W FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphodiesterase_I Phosphodiesterase I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.1 3.1.4.1] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5z6w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5z6w OCA], [http://pdbe.org/5z6w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5z6w RCSB], [http://www.ebi.ac.uk/pdbsum/5z6w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5z6w ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5z6w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5z6w OCA], [https://pdbe.org/5z6w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5z6w RCSB], [https://www.ebi.ac.uk/pdbsum/5z6w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5z6w ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/FAN1_PSEAE FAN1_PSEAE]] Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Also has endonuclease activity toward 5'-flaps (PubMed:25319828).[UniProtKB:Q9Y2M0]<ref>PMID:24981866</ref> <ref>PMID:25319828</ref>
[https://www.uniprot.org/uniprot/FAN1_PSEAE FAN1_PSEAE] Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Also has endonuclease activity toward 5'-flaps (PubMed:25319828).[UniProtKB:Q9Y2M0]<ref>PMID:24981866</ref> <ref>PMID:25319828</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Phosphodiesterase I]]
[[Category: Large Structures]]
[[Category: Cho, Y]]
[[Category: Pseudomonas aeruginosa PAO1]]
[[Category: Jin, H]]
[[Category: Synthetic construct]]
[[Category: Hydrolase-dna complex]]
[[Category: Cho Y]]
[[Category: Nuclease]]
[[Category: Jin H]]