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==Crystal structure of the T1L reovirus sigma1 coiled coil tail (iodide)==
==Crystal structure of the T1L reovirus sigma1 coiled coil tail (iodide)==
<StructureSection load='6gaj' size='340' side='right' caption='[[6gaj]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
<StructureSection load='6gaj' size='340' side='right'caption='[[6gaj]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6gaj]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GAJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GAJ FirstGlance]. <br>
<table><tr><td colspan='2'>[[6gaj]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mammalian_orthoreovirus_1_Lang Mammalian orthoreovirus 1 Lang]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GAJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6GAJ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.35&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gaj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gaj OCA], [http://pdbe.org/6gaj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gaj RCSB], [http://www.ebi.ac.uk/pdbsum/6gaj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gaj ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6gaj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gaj OCA], [https://pdbe.org/6gaj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6gaj RCSB], [https://www.ebi.ac.uk/pdbsum/6gaj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6gaj ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/SIGM1_REOVL SIGM1_REOVL]] Fiber-like molecule that attaches the virion to the host cell membrane by binding to the primary receptor F11R/JAM-A and to sialic acid containing proteins (coreceptor). The interaction of sigma-1 with F11R is required for NF-kB activation and apoptosis. Binding to both sialic acid and F11R is required to induce maximal levels of apoptosis (By similarity).  
[https://www.uniprot.org/uniprot/SIGM1_REOVL SIGM1_REOVL] Fiber-like molecule that attaches the virion to the host cell membrane by binding to the primary receptor F11R/JAM-A and to sialic acid containing proteins (coreceptor). The interaction of sigma-1 with F11R is required for NF-kB activation and apoptosis. Binding to both sialic acid and F11R is required to induce maximal levels of apoptosis (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Dietrich, M H]]
[[Category: Large Structures]]
[[Category: Stehle, T]]
[[Category: Mammalian orthoreovirus 1 Lang]]
[[Category: Cell attachment protein]]
[[Category: Dietrich MH]]
[[Category: Coiled coil]]
[[Category: Stehle T]]
[[Category: Reovirus sigma1]]
[[Category: Viral protein]]
Retrieved from "https://proteopedia.org/6gaj"