Elastase: Difference between revisions

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[[Elastase]] (ELA) is a chymotrypsin-like serine protease which breaks down proteins. The ELAs are numbered according to their genes. '''Panceatic ELA''' cleaves proteins at the carboxyl-terminal side of small neutral amino acids. It cleaves Ala-Ala and Ala-Gly bonds. <ref>PMID:12059069</ref> For additional details see [[Serine Proteases]].

[[Elastase]] (ELA) is a chymotrypsin-like serine protease which breaks down proteins. The ELAs are numbered according to their genes. '''Panceatic ELA''' cleaves proteins at the carboxyl-terminal side of small neutral amino acids. It cleaves Ala-Ala and Ala-Gly bonds. <ref>PMID:12059069</ref> For additional details see

*[[Protease]]

*[[Serine Proteases]].

== Relevance ==

'''ELA2''' (or PMN-ELA) is secreted by neutrophils during inflammation.

'''ELA1''' in the pancreas correlates well with exocrine pancreatic functioning and is used as a function test for patients with pancreatitis. '''ELA2''' (or PMN-ELA) is secreted by neutrophils during inflammation.

== Disease ==

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== Structural highlights ==

<scene name='41/411401/Cv/6'>Pig elastase</scene> (cyan, green) complex with <scene name='41/411401/Cv/5'>chymotrypsin/elastase isoinhibitor</scene> (magenta, yellow) (PDB code [[1eai]]). ELA <scene name='41/411401/Cv/7'>catalytic triad is Ser-His-Asp</scene>.<ref>PMID:7922044</ref>

<scene name='41/411401/Cv/8'>Pig elastase</scene> (cyan, green) complex with <scene name='41/411401/Cv/9'>chymotrypsin/elastase isoinhibitor</scene> (magenta, yellow) (PDB code [[1eai]]). ELA <scene name='41/411401/Cv/10'>catalytic triad is Ser-His-Asp</scene>.<ref>PMID:7922044</ref>

~~</StructureSection>~~

==3D structures of elastase==

[[Elastase 3D structures]]

~~Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}~~

</StructureSection>

~~{{#tree:id=OrganizedByTopic|openlevels=0|~~

* MMP12 See [[Matrix metalloproteinase]]

* MMP16 See [[Matrix metalloproteinase]]

* ELA1

**[[3mty]], [[3mu0]], [[3mu1]], [[3mu4]], [[3mu5]], [[3mu8]], [[3mnb]], [[3mnc]], [[3mns]], [[3mnx]], [[3mo3]], [[3mo6]], [[3mo9]], [[3moc]], [[3e3t]], [[2v0b]], [[2g4t]], [[2g4u]], [[2de8]], [[2blo]], [[2blq]], [[2a7c]], [[2a7j]], [[1gvk]], [[1qnj]], [[1lvy]], [[3est]], [[1est]], [[2oqu]], [[3odd]], [[3odf]], [[2bdc]] – pELA1 – pig<~~br />~~

**[[3hgn]] – pELA1+peptidyl inhibitor – neutron

**[[3hgp]], [[2cv3]], [[2bdb]], [[2bcd]], [[2h1u]], [[1mmj]], [[1h9l]], [[1nes]], [[4est]], [[5est]], [[8est]], [[7est]], [[6est]] - pELA1+peptidyl inhibitor

**[[1fzz]] – pELA1+ONO-6818

**[[1qr3]], [[1qgf]], [[1bru]], [[1hv7]], [[1btu]] – pELA1+cyclic inhibitor

**[[1okx]] – pELA1 + scyptolin

**[[1e34]], [[1e35]], [[1e36]], [[1e37]], [[1e38]] – pELA1-gamma-lactam

**[[1eai]] – pELA1+Ascaris inhibitor

**[[2d26]] – pELA1+α-1-antitrypsin

**[[1fle]] – pELA1+elafin

**[[1b0e]], [[1b0f]] – pELA1+MDL

**[[2v35]] – pELA1+JM54

**[[2iot]] – pELA1+clavulanic acid

**[[2de9]] – pELA1+tris

**[[1uvo]], [[1uvp]], [[1lka]], [[1lkb]] – pELA1+ions

**[[1gwa]] – pELA1+I3

**[[1uo6]], [[1c1m]] – pELA1+Xe

**[[1l0z]], [[1l1g]] - pELA1+Xe+Br

**[[2bb4]], [[2bd2]], [[2bd3]], [[2bd4]], [[2bd5]], [[2bd7]], [[2bd8]], [[2bd9]], [[1hax]], [[1hay]], [[1haz]], [[1hb0]], [[1qix]] – pELA1+beta-casomorphin-7

**[[2bda]] – pELA1+N-acetyl-NPI

**[[1mcv]] – pELA1+squash inhibitor

**[[1bma]] – pELA1+aminimide

**[[1elf]], [[1elg]] – pELA1+peptidyl hydroxylamine

**[[1eld]], [[1ele]], [[1elb]], [[1ela]], [[1elc]], [[2est]] – pELA1+anilide inhibitor

**[[1esa]], [[1esb]] – pELA1 intermediate

**[[1eas]], [[1eat]], [[1eau]] – pELA1+pyridine inhibitor

**[[1inc]] – pELA1+benzoxazinone

**[[1jim]], [[9est]], [[8est]] – pELA1+coumarin derivative

**[[2fo9]], [[2foa]], [[2fob]], [[2foc]], [[2fod]], [[2foe]], [[2fof]], [[2fog]], [[2foh]] – pELA1+solvent

**[[4k89]], [[1ezm]] – PaELA – ''Pseudomonas aeruginosa''

**[[3dbk]] – PaELA+phophoramidon

**[[1u4g]] – PaELA+HPI

**[[6f8b]] – PaELA + inhibitor

**[[1elt]] – ELA - salmon

* ELA2 or neutrophil elastase

**[[3q76]] – hELA2

**[[3q77]] – hELA2+dihydropyrimidone inhibitor

**[[2z7f]] – hELA2 peptidase domain +antileukoproteinase

**[[2rg3]] – hELA2+sulfonic inhibitor

**[[1h1b]], [[1ppg]], [[1hne]], [[5a09]], [[5a0a]], [[5a0b]], [[5a0c]], [[5a8x]], [[5a8y]], [[5a8z]], [[5abw]] – hELA2+inhibitor

**[[1ppf]] – hELA2+ovomucoid

**[[1b0f]] – hELA2+MDL101146

**[[4nzl]] – hELA2 + protein

**[[4wvp]] – hELA2 + activity-based probe

}}

== References ==

[[Category:Topic Page]]

@@ Line 1: / Line 1: @@
 <StructureSection load='1eai' size='350' side='right' caption='Pig elastase (cyan, green) complex with chymotrypsin/elastase isoinhibitor (magenta, yellow)  (PDB code [[1eai]]).' scene='41/411401/Cv/3'>
-[[Elastase]] (ELA) is a chymotrypsin-like serine protease which breaks down proteins.  The ELAs are numbered according to their genes.  '''Panceatic ELA''' cleaves proteins at the carboxyl-terminal side of small neutral amino acids.  It cleaves Ala-Ala and Ala-Gly bonds.  <ref>PMID:12059069</ref>  For additional details see [[Serine Proteases]].
+[[Elastase]] (ELA) is a chymotrypsin-like serine protease which breaks down proteins.  The ELAs are numbered according to their genes.  '''Panceatic ELA''' cleaves proteins at the carboxyl-terminal side of small neutral amino acids.  It cleaves Ala-Ala and Ala-Gly bonds.  <ref>PMID:12059069</ref>  For additional details see <br />
+*[[Protease]]<br />
+*[[Serine Proteases]].
 == Relevance ==
-'''ELA2''' (or PMN-ELA) is secreted by neutrophils during inflammation.
+'''ELA1''' in the pancreas correlates well with exocrine pancreatic functioning and is used as a function test for patients with pancreatitis.  '''ELA2''' (or PMN-ELA) is secreted by neutrophils during inflammation.
 == Disease ==
@@ Line 13: / Line 15: @@
 == Structural highlights ==
-<scene name='41/411401/Cv/6'>Pig elastase</scene> (cyan, green) complex with <scene name='41/411401/Cv/5'>chymotrypsin/elastase isoinhibitor</scene> (magenta, yellow)  (PDB code [[1eai]]). ELA <scene name='41/411401/Cv/7'>catalytic triad is Ser-His-Asp</scene>.<ref>PMID:7922044</ref>
+<scene name='41/411401/Cv/8'>Pig elastase</scene> (cyan, green) complex with <scene name='41/411401/Cv/9'>chymotrypsin/elastase isoinhibitor</scene> (magenta, yellow)  (PDB code [[1eai]]). ELA <scene name='41/411401/Cv/10'>catalytic triad is Ser-His-Asp</scene>.<ref>PMID:7922044</ref>
-</StructureSection>
 ==3D structures of elastase==
+[[Elastase 3D structures]]
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+</StructureSection>
-{{#tree:id=OrganizedByTopic|openlevels=0|
-* MMP12 See [[Matrix metalloproteinase]]
-* MMP16 See [[Matrix metalloproteinase]]
-* ELA1
-**[[3mty]], [[3mu0]], [[3mu1]], [[3mu4]], [[3mu5]], [[3mu8]], [[3mnb]], [[3mnc]], [[3mns]], [[3mnx]], [[3mo3]], [[3mo6]], [[3mo9]], [[3moc]], [[3e3t]], [[2v0b]], [[2g4t]], [[2g4u]], [[2de8]], [[2blo]], [[2blq]], [[2a7c]], [[2a7j]], [[1gvk]], [[1qnj]], [[1lvy]], [[3est]], [[1est]], [[2oqu]], [[3odd]], [[3odf]], [[2bdc]] – pELA1 – pig<br />
-**[[3hgn]] – pELA1+peptidyl inhibitor – neutron<br />
-**[[3hgp]], [[2cv3]], [[2bdb]], [[2bcd]], [[2h1u]], [[1mmj]], [[1h9l]], [[1nes]], [[4est]], [[5est]], [[8est]], [[7est]], [[6est]] - pELA1+peptidyl inhibitor<br />
-**[[1fzz]] – pELA1+ONO-6818<br />
-**[[1qr3]], [[1qgf]], [[1bru]], [[1hv7]], [[1btu]] – pELA1+cyclic inhibitor<br />
-**[[1okx]] – pELA1 + scyptolin<br />
-**[[1e34]], [[1e35]], [[1e36]], [[1e37]], [[1e38]] – pELA1-gamma-lactam<br />
-**[[1eai]] – pELA1+Ascaris inhibitor<br />
-**[[2d26]] – pELA1+α-1-antitrypsin<br />
-**[[1fle]] – pELA1+elafin<br />
-**[[1b0e]], [[1b0f]] – pELA1+MDL<br />
-**[[2v35]] – pELA1+JM54<br />
-**[[2iot]] – pELA1+clavulanic acid<br />
-**[[2de9]] – pELA1+tris<br />
-**[[1uvo]], [[1uvp]], [[1lka]], [[1lkb]] – pELA1+ions<br />
-**[[1gwa]] – pELA1+I3<br />
-**[[1uo6]], [[1c1m]] – pELA1+Xe<br />
-**[[1l0z]], [[1l1g]] - pELA1+Xe+Br<br />
-**[[2bb4]], [[2bd2]], [[2bd3]], [[2bd4]], [[2bd5]], [[2bd7]], [[2bd8]], [[2bd9]], [[1hax]], [[1hay]], [[1haz]], [[1hb0]], [[1qix]] – pELA1+beta-casomorphin-7<br />
-**[[2bda]] – pELA1+N-acetyl-NPI<br />
-**[[1mcv]] – pELA1+squash inhibitor<br />
-**[[1bma]] – pELA1+aminimide<br />
-**[[1elf]], [[1elg]] – pELA1+peptidyl hydroxylamine<br />
-**[[1eld]], [[1ele]], [[1elb]], [[1ela]], [[1elc]], [[2est]] – pELA1+anilide inhibitor<br />
-**[[1esa]], [[1esb]] – pELA1 intermediate<br />
-**[[1eas]], [[1eat]], [[1eau]] – pELA1+pyridine inhibitor<br />
-**[[1inc]] – pELA1+benzoxazinone<br />
-**[[1jim]], [[9est]], [[8est]] – pELA1+coumarin derivative<br />
-**[[2fo9]], [[2foa]], [[2fob]], [[2foc]], [[2fod]], [[2foe]], [[2fof]], [[2fog]], [[2foh]] – pELA1+solvent<br />
-**[[4k89]], [[1ezm]] – PaELA – ''Pseudomonas aeruginosa''<br />
-**[[3dbk]] – PaELA+phophoramidon <br />
-**[[1u4g]] – PaELA+HPI<br />
-**[[6f8b]] – PaELA + inhibitor<br />
-**[[1elt]] – ELA - salmon<br />
-* ELA2 or neutrophil elastase
-**[[3q76]] – hELA2<br />
-**[[3q77]] – hELA2+dihydropyrimidone inhibitor<br />
-**[[2z7f]] – hELA2 peptidase domain +antileukoproteinase<br />
-**[[2rg3]] – hELA2+sulfonic inhibitor<br />
-**[[1h1b]], [[1ppg]], [[1hne]], [[5a09]], [[5a0a]], [[5a0b]], [[5a0c]], [[5a8x]], [[5a8y]], [[5a8z]], [[5abw]] – hELA2+inhibitor<br />
-**[[1ppf]] – hELA2+ovomucoid<br />
-**[[1b0f]] – hELA2+MDL101146<br />
-**[[4nzl]] – hELA2 + protein <br />
-**[[4wvp]] – hELA2 + activity-based probe <br />
-}}
 == References ==
 <references/>
 [[Category:Topic Page]]

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