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==Crystal structure of human PRMT3 in complex with an allosteric inhibitor (PRMT3- KTD)==
==Crystal structure of human PRMT3 in complex with an allosteric inhibitor (PRMT3- KTD)==
<StructureSection load='4hsg' size='340' side='right' caption='[[4hsg]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='4hsg' size='340' side='right'caption='[[4hsg]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4hsg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HSG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HSG FirstGlance]. <br>
<table><tr><td colspan='2'>[[4hsg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HSG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HSG FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=KTD:1-(1,2,3-BENZOTHIADIAZOL-6-YL)-3-(2-OXO-2-PHENYLETHYL)UREA'>KTD</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PRMT3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=KTD:1-(1,2,3-BENZOTHIADIAZOL-6-YL)-3-(2-OXO-2-PHENYLETHYL)UREA'>KTD</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hsg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hsg OCA], [http://pdbe.org/4hsg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hsg RCSB], [http://www.ebi.ac.uk/pdbsum/4hsg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hsg ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hsg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hsg OCA], [https://pdbe.org/4hsg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hsg RCSB], [https://www.ebi.ac.uk/pdbsum/4hsg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hsg ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ANM3_HUMAN ANM3_HUMAN] Methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in some proteins.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C H]]
[[Category: Large Structures]]
[[Category: Bountra, C]]
[[Category: Arrowsmith CH]]
[[Category: Brown, P J]]
[[Category: Bountra C]]
[[Category: Dobrovetsky, E]]
[[Category: Brown PJ]]
[[Category: Dong, A]]
[[Category: Dobrovetsky E]]
[[Category: Edwards, A M]]
[[Category: Dong A]]
[[Category: Hajian, T]]
[[Category: Edwards AM]]
[[Category: Jin, J]]
[[Category: Hajian T]]
[[Category: Li, F]]
[[Category: Jin J]]
[[Category: Liu, F]]
[[Category: Li F]]
[[Category: Structural genomic]]
[[Category: Liu F]]
[[Category: Schapira, M]]
[[Category: Schapira M]]
[[Category: Siarheyeva, A]]
[[Category: Siarheyeva A]]
[[Category: Smil, D]]
[[Category: Smil D]]
[[Category: Tempel, W]]
[[Category: Tempel W]]
[[Category: Vedadi, M]]
[[Category: Vedadi M]]
[[Category: Allosteric inhibitor]]
[[Category: Prmt3]]
[[Category: Sgc]]
[[Category: Transferase-transferase inhibitor complex]]
Retrieved from "https://proteopedia.org/4hsg"