2i9p: Difference between revisions

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[[Image:2i9p.gif|left|200px]]


{{Structure
==Crystal structure of human hydroxyisobutyrate dehydrogenase complexed with NAD+==
|PDB= 2i9p |SIZE=350|CAPTION= <scene name='initialview01'>2i9p</scene>, resolution 2.55&Aring;
<StructureSection load='2i9p' size='340' side='right'caption='[[2i9p]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>
<table><tr><td colspan='2'>[[2i9p]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I9P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I9P FirstGlance]. <br>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/3-hydroxyisobutyrate_dehydrogenase 3-hydroxyisobutyrate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.31 1.1.1.31] </span>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.55&#8491;</td></tr>
|GENE= HIBADH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i9p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i9p OCA], [https://pdbe.org/2i9p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i9p RCSB], [https://www.ebi.ac.uk/pdbsum/2i9p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i9p ProSAT]</span></td></tr>
|RELATEDENTRY=[[2gf2|2GF2]]
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i9p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i9p OCA], [http://www.ebi.ac.uk/pdbsum/2i9p PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2i9p RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/3HIDH_HUMAN 3HIDH_HUMAN]
 
== Evolutionary Conservation ==
'''Crystal structure of human hydroxyisobutyrate dehydrogenase complexed with NAD+'''
[[Image:Consurf_key_small.gif|200px|right]]
 
Check<jmol>
 
  <jmolCheckbox>
==About this Structure==
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i9/2i9p_consurf.spt"</scriptWhenChecked>
2I9P is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I9P OCA].  
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
[[Category: 3-hydroxyisobutyrate dehydrogenase]]
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2i9p ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C.]]
[[Category: Arrowsmith C]]
[[Category: Burgess, N.]]
[[Category: Burgess N]]
[[Category: Delft, F Von.]]
[[Category: Edwards A]]
[[Category: Edwards, A.]]
[[Category: Kavanagh KL]]
[[Category: Kavanagh, K L.]]
[[Category: Lukacik P]]
[[Category: Lukacik, P.]]
[[Category: Oppermann U]]
[[Category: Oppermann, U.]]
[[Category: Papagrigoriou E]]
[[Category: Papagrigoriou, E.]]
[[Category: Salah E]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Smee C]]
[[Category: Salah, E.]]
[[Category: Sundstrom M]]
[[Category: Smee, C.]]
[[Category: Weigelt J]]
[[Category: Sundstrom, M.]]
[[Category: Von Delft F]]
[[Category: Weigelt, J.]]
[[Category: 3-hydroxyacid dehydrogenase]]
[[Category: sgc]]
[[Category: structural genomic]]
[[Category: structural genomics consortium]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:41:21 2008''

Latest revision as of 10:07, 30 August 2023

Crystal structure of human hydroxyisobutyrate dehydrogenase complexed with NAD+

2i9p, resolution 2.55Å

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