5zxa: Difference between revisions
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==Crystal structure of fibronectin-binding protein Apa mutant from Mycobacterium tuberculosis== | |||
<StructureSection load='5zxa' size='340' side='right'caption='[[5zxa]], [[Resolution|resolution]] 1.77Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5zxa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZXA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ZXA FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.77Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene></td></tr> | ||
[[Category: Chen | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5zxa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zxa OCA], [https://pdbe.org/5zxa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5zxa RCSB], [https://www.ebi.ac.uk/pdbsum/5zxa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5zxa ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: Guo | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/APA_MYCTU APA_MYCTU] A potent antigen in animals immunized with live bacteria, it induces a strong delayed-type hypersensitivity (DTH) in immunized animals (PubMed:10531201). Elicits a mostly Th1 type of T-cell response in healthy humans; induces IFN-gamma production from CD4(+) and CD8(+) cells (PubMed:12654810). Functions as an adhesin, binds to mouse macrophages via mannose residues (PubMed:10531201, PubMed:25359607). Might interact via host CD209 (PubMed:16092920).<ref>PMID:10531201</ref> <ref>PMID:12654810</ref> <ref>PMID:16092920</ref> <ref>PMID:25359607</ref> | ||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mycobacterium tuberculosis H37Rv]] | |||
[[Category: Chen CC]] | |||
[[Category: Gao J]] | |||
[[Category: Guo RT]] | |||
[[Category: Liu WD]] | |||
Latest revision as of 10:29, 27 March 2024
Crystal structure of fibronectin-binding protein Apa mutant from Mycobacterium tuberculosis
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