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==Crystal structure of E. coli RppH-DapF complex, monomer==
==Crystal structure of E. coli RppH-DapF complex, monomer==
<StructureSection load='6d1q' size='340' side='right' caption='[[6d1q]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
<StructureSection load='6d1q' size='340' side='right'caption='[[6d1q]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6d1q]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D1Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6D1Q FirstGlance]. <br>
<table><tr><td colspan='2'>[[6d1q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D1Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6D1Q FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Diaminopimelate_epimerase Diaminopimelate epimerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.1.7 5.1.1.7] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6d1q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d1q OCA], [http://pdbe.org/6d1q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6d1q RCSB], [http://www.ebi.ac.uk/pdbsum/6d1q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6d1q ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6d1q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d1q OCA], [https://pdbe.org/6d1q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6d1q RCSB], [https://www.ebi.ac.uk/pdbsum/6d1q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6d1q ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/DAPF_ECO45 DAPF_ECO45]] Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan. [[http://www.uniprot.org/uniprot/RPPH_ECO45 RPPH_ECO45]] Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
[https://www.uniprot.org/uniprot/DAPF_ECOLI DAPF_ECOLI] Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan. Only accepts DAP isomers with the L configuration.<ref>PMID:6378903</ref> <ref>PMID:3031013</ref> <ref>PMID:3042781</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Diaminopimelate epimerase]]
[[Category: Escherichia coli K-12]]
[[Category: Gao, A]]
[[Category: Large Structures]]
[[Category: Serganov, A]]
[[Category: Gao A]]
[[Category: Dapf]]
[[Category: Serganov A]]
[[Category: Isomerase-hydrolase complex]]
[[Category: Rna decay]]
[[Category: Rpph]]
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