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==Solution structures of the LIM domain of human NEDD9 interacting protein with calponin homology and LIM domains==
==Solution structures of the LIM domain of human NEDD9 interacting protein with calponin homology and LIM domains==
<StructureSection load='2co8' size='340' side='right' caption='[[2co8]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2co8' size='340' side='right'caption='[[2co8]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2co8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CO8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CO8 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2co8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CO8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CO8 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NICAL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2co8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2co8 OCA], [http://pdbe.org/2co8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2co8 RCSB], [http://www.ebi.ac.uk/pdbsum/2co8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2co8 ProSAT], [http://www.topsan.org/Proteins/RSGI/2co8 TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2co8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2co8 OCA], [https://pdbe.org/2co8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2co8 RCSB], [https://www.ebi.ac.uk/pdbsum/2co8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2co8 ProSAT], [https://www.topsan.org/Proteins/RSGI/2co8 TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/MICA1_HUMAN MICA1_HUMAN]] Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization (Probable). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4.<ref>PMID:18305261</ref> <ref>PMID:21864500</ref>
[https://www.uniprot.org/uniprot/MICA1_HUMAN MICA1_HUMAN] Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization (Probable). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4.<ref>PMID:18305261</ref> <ref>PMID:21864500</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Inoue, M]]
[[Category: Large Structures]]
[[Category: Kigawa, T]]
[[Category: Inoue M]]
[[Category: Koshiba, S]]
[[Category: Kigawa T]]
[[Category: Structural genomic]]
[[Category: Koshiba S]]
[[Category: Saito, K]]
[[Category: Saito K]]
[[Category: Sato, M]]
[[Category: Sato M]]
[[Category: Tomizawa, T]]
[[Category: Tomizawa T]]
[[Category: Yokoyama, S]]
[[Category: Yokoyama S]]
[[Category: Lim domain]]
[[Category: Metal binding protein]]
[[Category: National project on protein structural and functional analyse]]
[[Category: Nppsfa]]
[[Category: Rsgi]]
[[Category: Zinc finger protein]]
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