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[[Image:2ija.gif|left|200px]]


{{Structure
==Human N-acetyltransferase 1 F125S mutant==
|PDB= 2ija |SIZE=350|CAPTION= <scene name='initialview01'>2ija</scene>, resolution 1.701&Aring;
<StructureSection load='2ija' size='340' side='right'caption='[[2ija]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=ACM:ACETAMIDE'>ACM</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>
<table><tr><td colspan='2'>[[2ija]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IJA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IJA FirstGlance]. <br>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Arylamine_N-acetyltransferase Arylamine N-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.5 2.3.1.5] </span>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.701&#8491;</td></tr>
|GENE= NAT1, AAC1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACM:ACETAMIDE'>ACM</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ija FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ija OCA], [https://pdbe.org/2ija PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ija RCSB], [https://www.ebi.ac.uk/pdbsum/2ija PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ija ProSAT]</span></td></tr>
|RELATEDENTRY=
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ija FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ija OCA], [http://www.ebi.ac.uk/pdbsum/2ija PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ija RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/ARY1_HUMAN ARY1_HUMAN] Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ij/2ija_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ija ConSurf].
<div style="clear:both"></div>


'''Human N-acetyltransferase 1 F125S mutant'''
==See Also==
 
*[[Arylamine N-acetyltransferase 3D structures|Arylamine N-acetyltransferase 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
2IJA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IJA OCA].
[[Category: Arylamine N-acetyltransferase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C H.]]
[[Category: Arrowsmith CH]]
[[Category: Bochkarev, A.]]
[[Category: Bochkarev A]]
[[Category: Dombrovski, L.]]
[[Category: Dombrovski L]]
[[Category: Edwards, A M.]]
[[Category: Edwards AM]]
[[Category: Grant, D M.]]
[[Category: Grant DM]]
[[Category: Loppnau, P.]]
[[Category: Loppnau P]]
[[Category: Plotnikov, A N.]]
[[Category: Plotnikov AN]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Sundstrom M]]
[[Category: Sundstrom, M.]]
[[Category: Tempel W]]
[[Category: Tempel, W.]]
[[Category: Weigelt J]]
[[Category: Weigelt, J.]]
[[Category: Wu H]]
[[Category: Wu, H.]]
[[Category: arylamide acetylase 1]]
[[Category: arylamine n-acetyltransferase 1]]
[[Category: sgc]]
[[Category: structural genomic]]
[[Category: structural genomics consortium]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:45:03 2008''

Latest revision as of 01:04, 21 November 2024

Human N-acetyltransferase 1 F125S mutant

2ija, resolution 1.70Å

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