Formate dehydrogenase: Difference between revisions

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'''Formate dehydrogenase''' (FDH) catalyzes the reversible two-electron oxidation of formate to bicarbonate.  The product electron is donated to either [[NAD]]+ in NAD-dependent FDH or to Mo-dependent FDH where the electron is donated to a Fe<sub>4</sub>S<sub>4</sub> center and then to cytochrome.  The '''Mo-dependent FDH-H''' from ''E. coli'' contains SelCys, Mo, molybdopterin guanosine dinucleotide (MGD) cofactor and Fe<sub>4</sub>S<sub>4</sub><ref>PMID:2094290</ref>.   
'''Formate dehydrogenase''' (FDH) catalyzes the reversible two-electron oxidation of formate to bicarbonate.  The product electron is donated to either [[NAD]]+ in NAD-dependent FDH or to Mo-dependent FDH where the electron is donated to a Fe<sub>4</sub>S<sub>4</sub> center and then to cytochrome.  The '''Mo-dependent FDH-H''' from ''E. coli'' contains SelCys, Mo, molybdopterin guanosine dinucleotide (MGD) cofactor and Fe<sub>4</sub>S<sub>4</sub><ref>PMID:2094290</ref>.   
*<scene name='49/491980/Cv/6'>NAD binding site</scene> in NAD-dependent formate dehydrogenase ([[2nad]]). Water molecules shown as red spheres.
*<scene name='49/491980/Cv/8'>NAD binding site</scene> in NAD-dependent formate dehydrogenase ([[2nad]]). Water molecules shown as red spheres.
*<scene name='49/491980/Cv/7'>Azide ion binding site</scene>.  
*<scene name='49/491980/Cv/9'>Azide ion binding site</scene>.  
</StructureSection>
 
==3D structure of formate dehydrogenase==
==3D structure of formate dehydrogenase==
[[Formate dehydrogenase 3D structures]]


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
</StructureSection>
{{#tree:id=OrganizedByTopic|openlevels=0|
 
*NAD-dependent FDH
 
**[[2nac]], [[2go1]] – PsFDH – ''Pseudomonas''<BR />
**[[2fss]], [[5dna]] – CbFDH – ''Candida boidinii''<BR />
**[[2j6i]] – CbFDH C terminal (mutant) <BR />
**[[3fn4]] - MoFDH – ''Moraxella''<BR />
**[[3naq]], [[3jtm]] – ArFDH – ''Arabidopsis thaliana''<BR />
**[[2nad]] – PsFDH + NAD<BR />
**[[2gug]] – PsFDH + formate<BR />
**[[2gsd]] – MoFDH + NAD + N3<BR />
**[[3n7u]] - ArFDH + NAD + N3<BR />
**[[5dn9]] - CbFDH + NAD + N3<BR />
**[[3wr5]] – FDH + NAD – ''Thiobacillus''<br />
**[[4xyg]] – GmFDH – ''Granulicella mallensis''<br />
**[[4xyb]] – GmFDH + NADP <br />
**[[4xye]] – GmFDH + NAD<br />
 
*Mo-dependent FDH


**[[1aa6]], [[1fdo]], [[2iv2]] – EcFDH-H + Fe4S4 + MGD – ''Escherichia coli''<BR />
**[[1fdi]] - EcFDH-H + Fe4S4 + NO2 + MGD<BR />
**[[1kqf]] - EcFDH-N + Fe4S4 + protoporphyrin + MGD<BR />
**[[1kqg]] - EcFDH-N + Fe4S4 + protoporphyrin + heptyl-oxy-quinolinol + MGD<BR />
**[[1h0h]] - FDH + Fe4S4 +MGD – ''Desulfovibrio gigas''
}}
== References ==
== References ==
<references/>
<references/>


[[Category:Topic Page]]
[[Category:Topic Page]]

Latest revision as of 09:27, 3 July 2019

NAD-dependent formate dehydrogenase dimer complex with cofactor NAD and sulfate, 2nad

Drag the structure with the mouse to rotate

References

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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