6glq: Difference between revisions
From Proteopedia
Jump to navigationJump to search
New page: '''Unreleased structure''' The entry 6glq is ON HOLD Authors: Eberle, S.A., Wiedmer, L., Sledz, P., Caflisch, A. Description: hMTH1 N33G in complex with LW14. [[Category: Unreleased St... |
No edit summary |
||
| (3 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
==Crystal structure of hMTH1 N33G in complex with LW14 in the absence of acetate== | |||
<StructureSection load='6glq' size='340' side='right'caption='[[6glq]], [[Resolution|resolution]] 1.60Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6glq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GLQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6GLQ FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.601Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BU8:1~{H}-imidazo[4,5-b]pyridin-2-amine'>BU8</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6glq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6glq OCA], [https://pdbe.org/6glq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6glq RCSB], [https://www.ebi.ac.uk/pdbsum/6glq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6glq ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/8ODP_HUMAN 8ODP_HUMAN] Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP.<ref>PMID:10373420</ref> <ref>PMID:10608900</ref> <ref>PMID:11139615</ref> <ref>PMID:12857738</ref> <ref>PMID:22556419</ref> | |||
==See Also== | |||
*[[7%2C8-dihydro-8-oxoguanine triphosphatase 3D structures|7%2C8-dihydro-8-oxoguanine triphosphatase 3D structures]] | |||
== References == | |||
[[Category: | <references/> | ||
[[Category: Caflisch | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: Sledz | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Caflisch A]] | |||
[[Category: Eberle SA]] | |||
[[Category: Sledz P]] | |||
[[Category: Wiedmer L]] | |||
Latest revision as of 05:16, 21 November 2024
Crystal structure of hMTH1 N33G in complex with LW14 in the absence of acetate
| ||||||||||||
