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==Crystal Structure of EphA6/Odin Complex==
==Crystal Structure of EphA6/Odin Complex==
<StructureSection load='5zry' size='340' side='right' caption='[[5zry]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
<StructureSection load='5zry' size='340' side='right'caption='[[5zry]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5zry]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZRY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZRY FirstGlance]. <br>
<table><tr><td colspan='2'>[[5zry]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZRY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ZRY FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zry OCA], [http://pdbe.org/5zry PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zry RCSB], [http://www.ebi.ac.uk/pdbsum/5zry PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zry ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5zry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zry OCA], [https://pdbe.org/5zry PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5zry RCSB], [https://www.ebi.ac.uk/pdbsum/5zry PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5zry ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/ANS1A_MOUSE ANS1A_MOUSE]] Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction.<ref>PMID:17875921</ref>
[https://www.uniprot.org/uniprot/ANS1A_MOUSE ANS1A_MOUSE] Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction.<ref>PMID:17875921</ref> [https://www.uniprot.org/uniprot/EPHA6_MOUSE EPHA6_MOUSE] Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Receptor protein-tyrosine kinase]]
[[Category: Large Structures]]
[[Category: Chen, W]]
[[Category: Mus musculus]]
[[Category: Li, G]]
[[Category: Chen W]]
[[Category: Li, J]]
[[Category: Li G]]
[[Category: Liu, W]]
[[Category: Li J]]
[[Category: Shang, Y]]
[[Category: Liu W]]
[[Category: Wan, J]]
[[Category: Shang Y]]
[[Category: Wang, Y]]
[[Category: Wan J]]
[[Category: Zhang, M]]
[[Category: Wang Y]]
[[Category: Cell adhesion]]
[[Category: Zhang M]]
[[Category: Cell signaling]]
[[Category: Heterodimer]]
[[Category: Protein binding]]
[[Category: Receptor]]
[[Category: Sam domain]]
[[Category: Signaling protein]]
[[Category: Transmembrane]]
[[Category: Tyrosine-protein kinase]]
Retrieved from "https://proteopedia.org/5zry"