6c4u: Difference between revisions

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==Engineered FHA with Myc-pTBD peptide==
==Engineered FHA with Myc-pTBD peptide==
<StructureSection load='6c4u' size='340' side='right' caption='[[6c4u]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='6c4u' size='340' side='right'caption='[[6c4u]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6c4u]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C4U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6C4U FirstGlance]. <br>
<table><tr><td colspan='2'>[[6c4u]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C4U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6C4U FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6c4u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c4u OCA], [http://pdbe.org/6c4u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6c4u RCSB], [http://www.ebi.ac.uk/pdbsum/6c4u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6c4u ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6c4u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c4u OCA], [https://pdbe.org/6c4u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6c4u RCSB], [https://www.ebi.ac.uk/pdbsum/6c4u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6c4u ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RAD53_YEAST RAD53_YEAST] Controls S-phase checkpoint as well as G1 and G2 DNA damage checkpoints. Phosphorylates proteins on serine, threonine, and tyrosine. Prevents entry into anaphase and mitotic exit after DNA damage via regulation of the Polo kinase CDC5. Seems to be involved in the phosphorylation of RPH1.<ref>PMID:8355715</ref> <ref>PMID:7958905</ref> <ref>PMID:10550056</ref> <ref>PMID:11809875</ref> <ref>PMID:15024067</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Kall, S L]]
[[Category: Homo sapiens]]
[[Category: Lavie, A]]
[[Category: Large Structures]]
[[Category: Fha]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Myc pt58 target]]
[[Category: Kall SL]]
[[Category: Peptide binding protein]]
[[Category: Lavie A]]
[[Category: Protein engineering]]
Retrieved from "https://proteopedia.org/6c4u"