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[[Image:2ist.jpg|left|200px]]


{{Structure
==crystal structure of RluD from E. coli==
|PDB= 2ist |SIZE=350|CAPTION= <scene name='initialview01'>2ist</scene>, resolution 1.860&Aring;
<StructureSection load='2ist' size='340' side='right'caption='[[2ist]], [[Resolution|resolution]] 1.86&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=BCT:BICARBONATE+ION'>BCT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>
<table><tr><td colspan='2'>[[2ist]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IST OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IST FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.86&#8491;</td></tr>
|GENE= rluD, sfhB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BCT:BICARBONATE+ION'>BCT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ist FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ist OCA], [https://pdbe.org/2ist PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ist RCSB], [https://www.ebi.ac.uk/pdbsum/2ist PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ist ProSAT]</span></td></tr>
|RELATEDENTRY=[[1qyu|1QYU]], [[1prz|1PRZ]], [[1v9f|1V9F]]
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ist FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ist OCA], [http://www.ebi.ac.uk/pdbsum/2ist PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ist RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/RLUD_ECOLI RLUD_ECOLI] Responsible for synthesis of pseudouridine from uracil at positions 1911, 1915 and 1917 in 23S ribosomal RNA. Isomerization occurs as a late step during the assembly of the large ribosomal subunit.<ref>PMID:11087118</ref> <ref>PMID:17937767</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/is/2ist_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ist ConSurf].
<div style="clear:both"></div>


'''crystal structure of RluD from E. coli'''
==See Also==
 
*[[Guide-independent Pseudouridine synthase|Guide-independent Pseudouridine synthase]]
 
*[[Pseudouridine synthase 3D structures|Pseudouridine synthase 3D structures]]
==About this Structure==
== References ==
2IST is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IST OCA].
<references/>
__TOC__
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Finer-Moore, J S.]]
[[Category: Finer-Moore JS]]
[[Category: Foster, P G.]]
[[Category: Foster PG]]
[[Category: Stroud, R M.]]
[[Category: Stroud RM]]
[[Category: alpha-beta fold]]
[[Category: pseudouridine synthase]]
[[Category: s4 domain]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:48:06 2008''
Retrieved from "https://proteopedia.org/2ist"