2dnc: Difference between revisions
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==Solution Structure of RSGI RUH-054, a lipoyl domain from human 2-oxoacid dehydrogenase== | ==Solution Structure of RSGI RUH-054, a lipoyl domain from human 2-oxoacid dehydrogenase== | ||
<StructureSection load='2dnc' size='340' side='right' caption='[[2dnc | <StructureSection load='2dnc' size='340' side='right'caption='[[2dnc]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2dnc]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2dnc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DNC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DNC FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dnc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dnc OCA], [https://pdbe.org/2dnc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dnc RCSB], [https://www.ebi.ac.uk/pdbsum/2dnc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dnc ProSAT], [https://www.topsan.org/Proteins/RSGI/2dnc TOPSAN]</span></td></tr> | |||
</table> | </table> | ||
== Disease == | == Disease == | ||
[ | [https://www.uniprot.org/uniprot/ODPX_HUMAN ODPX_HUMAN] Defects in PDHX are the cause of pyruvate dehydrogenase E3-binding protein deficiency (PDHXD) [MIM:[https://omim.org/entry/245349 245349].<ref>PMID:9399911</ref> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/ODPX_HUMAN ODPX_HUMAN] Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
*[[Pyruvate dehydrogenase|Pyruvate dehydrogenase]] | *[[Pyruvate dehydrogenase 3D structures|Pyruvate dehydrogenase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Hayashi | [[Category: Large Structures]] | ||
[[Category: Hirota | [[Category: Hayashi F]] | ||
[[Category: Kurosaki | [[Category: Hirota H]] | ||
[[Category: Momen | [[Category: Kurosaki C]] | ||
[[Category: Ruhul Momen AZM]] | |||
[[Category: Yokoyama | [[Category: Yokoyama S]] | ||
[[Category: Yoshida | [[Category: Yoshida M]] | ||
Latest revision as of 18:44, 29 May 2024
Solution Structure of RSGI RUH-054, a lipoyl domain from human 2-oxoacid dehydrogenase
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