6dd3: Difference between revisions
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==Crystal structure of the double mutant (D52N/D407A) of NT5C2-537X in the active state== | |||
<StructureSection load='6dd3' size='340' side='right'caption='[[6dd3]], [[Resolution|resolution]] 1.98Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6dd3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DD3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DD3 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.98Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | ||
[[Category: Carpenter | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6dd3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dd3 OCA], [https://pdbe.org/6dd3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6dd3 RCSB], [https://www.ebi.ac.uk/pdbsum/6dd3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6dd3 ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Disease == | ||
[[Category: | [https://www.uniprot.org/uniprot/5NTC_HUMAN 5NTC_HUMAN] Autosomal recessive spastic paraplegia type 45. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:24482476</ref> | ||
[[Category: Kirschner-Schwabe | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/5NTC_HUMAN 5NTC_HUMAN] May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotides. | ||
[[Category: Sanchez-Martin | == References == | ||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Ambesi-Impiombato A]] | |||
[[Category: Carpenter Z]] | |||
[[Category: Dieck CL]] | |||
[[Category: Ferrando AA]] | |||
[[Category: Forouhar F]] | |||
[[Category: Kirschner-Schwabe R]] | |||
[[Category: Lew S]] | |||
[[Category: Sanchez-Martin M]] | |||
[[Category: Seetharaman J]] | |||
[[Category: Tong L]] | |||
[[Category: Tzoneva G]] | |||
Latest revision as of 14:33, 13 March 2024
Crystal structure of the double mutant (D52N/D407A) of NT5C2-537X in the active state
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