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==The Crystal Structure of Amyloid Precursor-Like Protein 2 (APLP2) E2 Domain==
==The Crystal Structure of Amyloid Precursor-Like Protein 2 (APLP2) E2 Domain==
<StructureSection load='5tpt' size='340' side='right' caption='[[5tpt]], [[Resolution|resolution]] 2.42&Aring;' scene=''>
<StructureSection load='5tpt' size='340' side='right'caption='[[5tpt]], [[Resolution|resolution]] 2.42&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5tpt]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TPT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TPT FirstGlance]. <br>
<table><tr><td colspan='2'>[[5tpt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TPT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5TPT FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tpt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tpt OCA], [http://pdbe.org/5tpt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tpt RCSB], [http://www.ebi.ac.uk/pdbsum/5tpt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tpt ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.422&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5tpt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tpt OCA], [https://pdbe.org/5tpt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5tpt RCSB], [https://www.ebi.ac.uk/pdbsum/5tpt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5tpt ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/APLP2_HUMAN APLP2_HUMAN]] May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity).<ref>PMID:8307156</ref>
[https://www.uniprot.org/uniprot/APLP2_HUMAN APLP2_HUMAN] May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity).<ref>PMID:8307156</ref>  
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Cappai, R]]
[[Category: Homo sapiens]]
[[Category: Roisman, L C]]
[[Category: Large Structures]]
[[Category: Alzheimer's disease]]
[[Category: Cappai R]]
[[Category: Amyloid precursor protein family]]
[[Category: Roisman LC]]
[[Category: Protein fibril]]
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