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==Crystal structure of TnmS3 in complex with tiancimycin (TNM B)==
==Crystal structure of TnmS3 in complex with tiancimycin (TNM B)==
<StructureSection load='5w27' size='340' side='right' caption='[[5w27]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='5w27' size='340' side='right'caption='[[5w27]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5w27]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5W27 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5W27 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5w27]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_sp._CB03234 Streptomyces sp. CB03234]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5W27 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5W27 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9VG:methyl+(2E)-3-[(1aS,11S,11aS,14Z,18R)-3,18-dihydroxy-4,9-dioxo-4,9,10,11-tetrahydro-11aH-11,1a-hept[3]ene[1,5]diynonaphtho[2,3-h]oxireno[c]quinolin-11a-yl]but-2-enoate'>9VG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5w29|5w29]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9VG:methyl+(2E)-3-[(1aS,11S,11aS,14Z,18R)-3,18-dihydroxy-4,9-dioxo-4,9,10,11-tetrahydro-11aH-11,1a-hept[3]ene[1,5]diynonaphtho[2,3-h]oxireno[c]quinolin-11a-yl]but-2-enoate'>9VG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5w27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5w27 OCA], [http://pdbe.org/5w27 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5w27 RCSB], [http://www.ebi.ac.uk/pdbsum/5w27 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5w27 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5w27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5w27 OCA], [https://pdbe.org/5w27 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5w27 RCSB], [https://www.ebi.ac.uk/pdbsum/5w27 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5w27 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A125SA29_9ACTN A0A125SA29_9ACTN]
==See Also==
*[[Dioxygenase 3D structures|Dioxygenase 3D structures]]
*[[Glyoxalase 3D structures|Glyoxalase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Chang, C]]
[[Category: Large Structures]]
[[Category: Chang, C Y]]
[[Category: Streptomyces sp. CB03234]]
[[Category: Joachimiak, A]]
[[Category: Chang C]]
[[Category: Structural genomic]]
[[Category: Chang CY]]
[[Category: NatPro, Enzyme Discovery for Natural Product Biosynthesis]]
[[Category: Joachimiak A]]
[[Category: Nocek, B]]
[[Category: Nocek B]]
[[Category: Phillips, G N]]
[[Category: Phillips Jr GN]]
[[Category: Rudolf, J D]]
[[Category: Rudolf JD]]
[[Category: SHen, B]]
[[Category: SHen B]]
[[Category: Biosynthetic protein]]
[[Category: Enzyme discovery for natural product biosynthesis]]
[[Category: Glyoxalase/bleomycin resistance protein/dioxygenase superfamily]]
[[Category: Lyase]]
[[Category: Mcsg]]
[[Category: Natpro]]
[[Category: Psi-biology]]
[[Category: Tiancimycin-binding protein]]

Latest revision as of 14:05, 4 October 2023

Crystal structure of TnmS3 in complex with tiancimycin (TNM B)

5w27, resolution 1.80Å

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