2ec1: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
 
(One intermediate revision by the same user not shown)
Line 1: Line 1:


==Solution structure of the RanBD1 domain from human Nucleoporin 50 kDa==
==Solution structure of the RanBD1 domain from human Nucleoporin 50 kDa==
<StructureSection load='2ec1' size='340' side='right' caption='[[2ec1]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2ec1' size='340' side='right'caption='[[2ec1]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2ec1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EC1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EC1 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2ec1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EC1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EC1 FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NUP50, NPAP60L, PRO1146 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ec1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ec1 OCA], [http://pdbe.org/2ec1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ec1 RCSB], [http://www.ebi.ac.uk/pdbsum/2ec1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ec1 ProSAT], [http://www.topsan.org/Proteins/RSGI/2ec1 TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ec1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ec1 OCA], [https://pdbe.org/2ec1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ec1 RCSB], [https://www.ebi.ac.uk/pdbsum/2ec1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ec1 ProSAT], [https://www.topsan.org/Proteins/RSGI/2ec1 TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/NUP50_HUMAN NUP50_HUMAN]] Component of the nuclear pore complex that has a direct role in nuclear protein import. Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta-cargo complex and importin recycling. Interacts with multiple transport receptor proteins including CDKN1B. This interaction is required for correct intracellular transport and degradation of CDKN1B.<ref>PMID:20016008</ref>
[https://www.uniprot.org/uniprot/NUP50_HUMAN NUP50_HUMAN] Component of the nuclear pore complex that has a direct role in nuclear protein import. Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta-cargo complex and importin recycling. Interacts with multiple transport receptor proteins including CDKN1B. This interaction is required for correct intracellular transport and degradation of CDKN1B.<ref>PMID:20016008</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 21: Line 21:


==See Also==
==See Also==
*[[Nucleoporin|Nucleoporin]]
*[[Nucleoporin 3D structures|Nucleoporin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Hayashi, F]]
[[Category: Large Structures]]
[[Category: Kurosaki, C]]
[[Category: Hayashi F]]
[[Category: Structural genomic]]
[[Category: Kurosaki C]]
[[Category: Yokoyama, S]]
[[Category: Yokoyama S]]
[[Category: Yoshida, M]]
[[Category: Yoshida M]]
[[Category: Zhang, H P]]
[[Category: Zhang HP]]
[[Category: National project on protein structural and functional analyse]]
[[Category: Nppsfa]]
[[Category: Nuclear pore-associated protein 60 kda-like]]
[[Category: Nucleoporin 50 kda]]
[[Category: Ranbp domain]]
[[Category: Rsgi]]
[[Category: Transport protein]]
Retrieved from "https://proteopedia.org/2ec1"