6dmj: Difference between revisions
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New page: '''Unreleased structure''' The entry 6dmj is ON HOLD Authors: Description: Category: Unreleased Structures |
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==A multiconformer ligand model of inhibitor 53W bound to CREB binding protein bromodomain== | |||
<StructureSection load='6dmj' size='340' side='right'caption='[[6dmj]], [[Resolution|resolution]] 1.15Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6dmj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DMJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DMJ FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.15Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=53W:5-(3,5-DIMETHYL-1,2-OXAZOL-4-YL)-2-[2-(4-METHOXYPHENYL)ETHYL]-1-[2-(MORPHOLIN-4-YL)ETHYL]-1H-BENZIMIDAZOLE'>53W</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6dmj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dmj OCA], [https://pdbe.org/6dmj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6dmj RCSB], [https://www.ebi.ac.uk/pdbsum/6dmj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6dmj ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). | |||
==See Also== | |||
*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]] | |||
*[[CREB-binding protein 3D structures|CREB-binding protein 3D structures]] | |||
[[Category: | == References == | ||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Borrelli K]] | |||
[[Category: Day T]] | |||
[[Category: Fonseca R]] | |||
[[Category: Fraser JS]] | |||
[[Category: Heliou A]] | |||
[[Category: Hudson BM]] | |||
[[Category: Keedy D]] | |||
[[Category: Suresh P]] | |||
[[Category: Van Zundert G]] | |||
[[Category: Van den Bedem H]] | |||
Latest revision as of 14:35, 13 March 2024
A multiconformer ligand model of inhibitor 53W bound to CREB binding protein bromodomain
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