5yxb: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 5yxb is ~~ON HOLD until Paper Publication~~

==A ligand binding to FXR==

== Structural highlights ==

<table><tr><td colspan='2'>[[5yxb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YXB OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=5YXB FirstGlance].

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.95Å</td></tr>

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=93O:2-methoxyethyl+(2E)-3-phenylprop-2-en-1-yl+2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate'>93O</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=5yxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yxb OCA], [https://pdbe.org/5yxb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5yxb RCSB], [https://www.ebi.ac.uk/pdbsum/5yxb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5yxb ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/NR1H4_HUMAN NR1H4_HUMAN] Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.<ref>PMID:10334992</ref> <ref>PMID:10334993</ref> <ref>PMID:12815072</ref> <ref>PMID:15471871</ref> <ref>PMID:12718892</ref> <ref>PMID:18621523</ref> <ref>PMID:19410460</ref> <ref>PMID:19586769</ref>

~~Authors~~:

==See Also==

*[[Bile acid receptor 3D structures|Bile acid receptor 3D structures]]

~~Description~~:

== References ==

[[Category: ~~Unreleased Structures~~]]

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Yi L]]

[[Category: Yong L]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5yxb is ON HOLD  until Paper Publication
+==A ligand binding to FXR==
+<StructureSection load='5yxb' size='340' side='right'caption='[[5yxb]], [[Resolution|resolution]] 2.95&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5yxb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YXB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5YXB FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.95&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=93O:2-methoxyethyl+(2E)-3-phenylprop-2-en-1-yl+2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate'>93O</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5yxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yxb OCA], [https://pdbe.org/5yxb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5yxb RCSB], [https://www.ebi.ac.uk/pdbsum/5yxb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5yxb ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/NR1H4_HUMAN NR1H4_HUMAN] Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.<ref>PMID:10334992</ref> <ref>PMID:10334993</ref> <ref>PMID:12815072</ref> <ref>PMID:15471871</ref> <ref>PMID:12718892</ref> <ref>PMID:18621523</ref> <ref>PMID:19410460</ref> <ref>PMID:19586769</ref>
-Authors:
+==See Also==
+*[[Bile acid receptor 3D structures|Bile acid receptor 3D structures]]
-Description:
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Yi L]]
+[[Category: Yong L]]