6fzb: Difference between revisions

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==AadA in complex with ATP, magnesium and streptomycin==
==AadA in complex with ATP, magnesium and streptomycin==
<StructureSection load='6fzb' size='340' side='right' caption='[[6fzb]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
<StructureSection load='6fzb' size='340' side='right'caption='[[6fzb]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6fzb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Salty Salty]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FZB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FZB FirstGlance]. <br>
<table><tr><td colspan='2'>[[6fzb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium_str._LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FZB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6FZB FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SRY:STREPTOMYCIN'>SRY</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5g4a|5g4a]], [[5luh|5luh]], [[5lpa|5lpa]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SRY:STREPTOMYCIN'>SRY</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">aadA, STM1264 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=99287 SALTY])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6fzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fzb OCA], [https://pdbe.org/6fzb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6fzb RCSB], [https://www.ebi.ac.uk/pdbsum/6fzb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6fzb ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Streptomycin_3''-adenylyltransferase Streptomycin 3''-adenylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.47 2.7.7.47] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fzb OCA], [http://pdbe.org/6fzb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fzb RCSB], [http://www.ebi.ac.uk/pdbsum/6fzb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fzb ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/S3AD_SALTY S3AD_SALTY] Mediates bacterial resistance to the antibiotics streptomycin and spectinomycin, does not confer resistance to kanamycin (PubMed:26527143). Binds ATP first, then antibiotic (PubMed:26527143, PubMed:29871922).<ref>PMID:26527143</ref> <ref>PMID:29871922</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Salty]]
[[Category: Large Structures]]
[[Category: Streptomycin 3''-adenylyltransferase]]
[[Category: Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]]
[[Category: P, S Kanchugal]]
[[Category: Kanchugal P S]]
[[Category: Selmer, M]]
[[Category: Selmer M]]
[[Category: Aminoglycoside adenyl transferase]]
[[Category: Antibiotic resistance]]
[[Category: Transferase]]
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