2ggr: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,332,843 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,332,843 edits
No edit summary
 
(One intermediate revision by the same user not shown)
Line 1: Line 1:


==Solution structure of the C-terminal SH3 domain of c-CrkII==
==Solution structure of the C-terminal SH3 domain of c-CrkII==
<StructureSection load='2ggr' size='340' side='right' caption='[[2ggr]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2ggr' size='340' side='right'caption='[[2ggr]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2ggr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GGR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GGR FirstGlance]. <br>
<table><tr><td colspan='2'>[[2ggr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GGR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GGR FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1cka|1cka]], [[1jeg|1jeg]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Crk, Crko ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ggr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ggr OCA], [https://pdbe.org/2ggr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ggr RCSB], [https://www.ebi.ac.uk/pdbsum/2ggr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ggr ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ggr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ggr OCA], [http://pdbe.org/2ggr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ggr RCSB], [http://www.ebi.ac.uk/pdbsum/2ggr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ggr ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CRK_MOUSE CRK_MOUSE]] The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk-II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.  
[https://www.uniprot.org/uniprot/CRK_MOUSE CRK_MOUSE] The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk-II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 31: Line 30:


==See Also==
==See Also==
*[[Adapter molecule crk|Adapter molecule crk]]
*[[Adapter molecule crk 3D structures|Adapter molecule crk 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Lk3 transgenic mice]]
[[Category: Large Structures]]
[[Category: Cowburn, D]]
[[Category: Mus musculus]]
[[Category: Dutta, K]]
[[Category: Cowburn D]]
[[Category: Muir, T W]]
[[Category: Dutta K]]
[[Category: Muralidharan, V]]
[[Category: Muir TW]]
[[Category: Crk-ii]]
[[Category: Muralidharan V]]
[[Category: Protein binding]]
[[Category: Sh3 domain]]
[[Category: Solution structure]]
Retrieved from "https://proteopedia.org/2ggr"