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[[Image:2jot.gif|left|200px]]


{{Structure
==Nuclear Magnetic Resonance Studies on Huwentoxin-XI from the Chinese Bird Spider Ornithoctonus huwena==
|PDB= 2jot |SIZE=350|CAPTION= <scene name='initialview01'>2jot</scene>
<StructureSection load='2jot' size='340' side='right'caption='[[2jot]]' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND=  
<table><tr><td colspan='2'>[[2jot]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Cyriopagopus_schmidti Cyriopagopus schmidti]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JOT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JOT FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
|GENE=  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jot FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jot OCA], [https://pdbe.org/2jot PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jot RCSB], [https://www.ebi.ac.uk/pdbsum/2jot PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jot ProSAT]</span></td></tr>
|DOMAIN=
</table>
|RELATEDENTRY=
== Function ==
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jot FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jot OCA], [http://www.ebi.ac.uk/pdbsum/2jot PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2jot RCSB]</span>
[https://www.uniprot.org/uniprot/VKT1A_CYRSC VKT1A_CYRSC] Dual-function toxin that inhibits both serine proteases (trypsin) and voltage-gated potassium channels (Kv). The toxin is more active on Kv1.1/KCNA1 (78% inhibition), than on Kv1.2/KCNA2 (10% inhibition), and Kv1.3/KCNA3 (28% inhibition), although a high dose (5 uM) is needed. The inhibition of potassium channels is voltage-dependent.<ref>PMID:15066414</ref> <ref>PMID:16820861</ref>
}}
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
'''Nuclear Magnetic Resonance Studies on Huwentoxin-XI from the Chinese Bird Spider Ornithoctonus huwena'''
Check<jmol>
 
  <jmolCheckbox>
 
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jo/2jot_consurf.spt"</scriptWhenChecked>
==About this Structure==
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
2JOT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Ornithoctonus_huwena Ornithoctonus huwena]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JOT OCA].  
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: Ornithoctonus huwena]]
  </jmolCheckbox>
[[Category: Single protein]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jot ConSurf].
[[Category: Liang, S.]]
<div style="clear:both"></div>
[[Category: Peng, K.]]
== References ==
[[Category: proteinase inhibitor]]
<references/>
 
__TOC__
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:00:16 2008''
</StructureSection>
[[Category: Cyriopagopus schmidti]]
[[Category: Large Structures]]
[[Category: Liang S]]
[[Category: Peng K]]
Retrieved from "https://proteopedia.org/2jot"