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[[Image:2js7.jpg|left|200px]]


{{Structure
==Solution NMR structure of human myeloid differentiation primary response (MyD88). Northeast Structural Genomics target HR2869A==
|PDB= 2js7 |SIZE=350|CAPTION= <scene name='initialview01'>2js7</scene>
<StructureSection load='2js7' size='340' side='right'caption='[[2js7]]' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND=  
<table><tr><td colspan='2'>[[2js7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JS7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JS7 FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
|GENE= MYD88 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2js7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2js7 OCA], [https://pdbe.org/2js7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2js7 RCSB], [https://www.ebi.ac.uk/pdbsum/2js7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2js7 ProSAT], [https://www.topsan.org/Proteins/NESGC/2js7 TOPSAN]</span></td></tr>
|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=smart00255 TIR]</span>
</table>
|RELATEDENTRY=
== Disease ==
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2js7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2js7 OCA], [http://www.ebi.ac.uk/pdbsum/2js7 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2js7 RCSB]</span>
[https://www.uniprot.org/uniprot/MYD88_HUMAN MYD88_HUMAN] Defects in MYD88 are the cause of MYD88 deficiency (MYD88D) [MIM:[https://omim.org/entry/612260 612260]; also known as recurrent pyogenic bacterial infections due to MYD88 deficiency. Patients suffer from autosomal recessive, life-threatening, often recurrent pyogenic bacterial infections, including invasive pneumococcal disease, and die between 1 and 11 months of age. Surviving patients are otherwise healthy, with normal resistance to other microbes, and their clinical status improved with age.<ref>PMID:19506249</ref> <ref>PMID:18669862</ref>
}}
== Function ==
 
[https://www.uniprot.org/uniprot/MYD88_HUMAN MYD88_HUMAN] Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity).<ref>PMID:9013863</ref> <ref>PMID:15361868</ref> <ref>PMID:18292575</ref> <ref>PMID:19506249</ref>
'''Solution NMR structure of human myeloid differentiation primary response (MyD88). Northeast Structural Genomics target HR2869A'''
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
 
Check<jmol>
==About this Structure==
  <jmolCheckbox>
2JS7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JS7 OCA].  
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/js/2js7_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2js7 ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Acton, T B.]]
[[Category: Acton TB]]
[[Category: Ciano, M.]]
[[Category: Ciano M]]
[[Category: Ho, C.]]
[[Category: Ho C]]
[[Category: Kennedy, M A.]]
[[Category: Kennedy MA]]
[[Category: Ma, L-C.]]
[[Category: Ma L-C]]
[[Category: Montelione, G T.]]
[[Category: Montelione GT]]
[[Category: NESG, Northeast Structural Genomics Consortium.]]
[[Category: Ramelot TA]]
[[Category: Ramelot, T A.]]
[[Category: Rossi P]]
[[Category: Rossi, P.]]
[[Category: Tao X]]
[[Category: Tong, L.]]
[[Category: Tong L]]
[[Category: Xiao, R.]]
[[Category: Xiao R]]
[[Category: innate immune signaling]]
[[Category: myd88_human]]
[[Category: nesg]]
[[Category: northeast structural genomics consortium]]
[[Category: protein structure initiative]]
[[Category: psi-2]]
[[Category: signaling protein]]
[[Category: structural genomic]]
[[Category: tir domain]]
[[Category: toll like receptor adaptor domain]]
 
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Retrieved from "https://proteopedia.org/2js7"