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==Crystal structure of TTHA0676 from Thermus thermophilus HB8==
==Crystal structure of TTHA0676 from Thermus thermophilus HB8==
<StructureSection load='2htm' size='340' side='right' caption='[[2htm]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='2htm' size='340' side='right'caption='[[2htm]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2htm]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/"flavobacterium_thermophilum"_yoshida_and_oshima_1971 "flavobacterium thermophilum" yoshida and oshima 1971]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HTM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HTM FirstGlance]. <br>
<table><tr><td colspan='2'>[[2htm]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HTM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HTM FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2htm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2htm OCA], [http://pdbe.org/2htm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2htm RCSB], [http://www.ebi.ac.uk/pdbsum/2htm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2htm ProSAT], [http://www.topsan.org/Proteins/RSGI/2htm TOPSAN]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2htm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2htm OCA], [https://pdbe.org/2htm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2htm RCSB], [https://www.ebi.ac.uk/pdbsum/2htm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2htm ProSAT], [https://www.topsan.org/Proteins/RSGI/2htm TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/THIG_THET8 THIG_THET8]] Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity).  
[https://www.uniprot.org/uniprot/THIG_THET8 THIG_THET8] Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ht/2htm_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ht/2htm_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Flavobacterium thermophilum yoshida and oshima 1971]]
[[Category: Large Structures]]
[[Category: Kunishima, N]]
[[Category: Thermus thermophilus]]
[[Category: Structural genomic]]
[[Category: Kunishima N]]
[[Category: Sugahara, M]]
[[Category: Sugahara M]]
[[Category: Biosynthetic protein]]
[[Category: National project on protein structural and functional analyse]]
[[Category: Nppsfa]]
[[Category: Rsgi]]
[[Category: Thermus thermophilus hb8]]
[[Category: Thiamin biosynthesis]]
[[Category: Thig]]

Latest revision as of 08:09, 30 October 2024

Crystal structure of TTHA0676 from Thermus thermophilus HB8

2htm, resolution 2.30Å

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