6dvl: Difference between revisions

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'''Unreleased structure'''


The entry 6dvl is ON HOLD  until Paper Publication
==Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with DDK-115==
<StructureSection load='6dvl' size='340' side='right'caption='[[6dvl]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6dvl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DVL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DVL FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HBG:N-[2-(cyclohexylamino)-2-oxoethyl]-N-{[4-(hydroxycarbamoyl)phenyl]methyl}-3,5-dimethylbenzamide'>HBG</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6dvl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dvl OCA], [https://pdbe.org/6dvl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6dvl RCSB], [https://www.ebi.ac.uk/pdbsum/6dvl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6dvl ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/F8W4B7_DANRE F8W4B7_DANRE]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Four crystal structures are presented of histone deacetylase 6 (HDAC6) complexes with para-substituted phenylhydromaxamate inhibitors, including bulky peptoids. These structures provide insight regarding the design of capping groups that confer selectivity for binding to HDAC6, specifically with regard to interactions in a pocket formed by the L1 loop. Capping group interactions may also influence hydroxamate-Zn(2+) coordination with monodentate or bidentate geometry.


Authors: Porter, N.J., Christianson, D.W.
Histone Deacetylase 6-Selective Inhibitors and the Influence of Capping Groups on Hydroxamate-Zinc Denticity.,Porter NJ, Osko JD, Diedrich D, Kurz T, Hooker JM, Hansen FK, Christianson DW J Med Chem. 2018 Aug 17. doi: 10.1021/acs.jmedchem.8b01013. PMID:30118224<ref>PMID:30118224</ref>


Description: Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with DDK-115
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
[[Category: Christianson, D.W]]
<div class="pdbe-citations 6dvl" style="background-color:#fffaf0;"></div>
[[Category: Porter, N.J]]
 
==See Also==
*[[Histone deacetylase 3D structures|Histone deacetylase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Danio rerio]]
[[Category: Large Structures]]
[[Category: Christianson DW]]
[[Category: Porter NJ]]
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