6fcx: Difference between revisions

<StructureSection load='6fcx' size='340' side='right' caption='[[6fcx]], [[Resolution|resolution]] 2.50&Aring;' scene=''>

<table><tr><td colspan='2'>[[6fcx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FCX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FCX FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>

<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MTHFR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>

<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methylenetetrahydrofolate_reductase_(NAD(P)H) Methylenetetrahydrofolate reductase (NAD(P)H)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.20 1.5.1.20] </span></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fcx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fcx OCA], [http://pdbe.org/6fcx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fcx RCSB], [http://www.ebi.ac.uk/pdbsum/6fcx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fcx ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/MTHR_HUMAN MTHR_HUMAN]] Thoracolumbosacral spina bifida cystica;Cervicothoracic spina bifida cystica;Lumbosacral spina bifida cystica;Homocystinuria due to methylene tetrahydrofolate reductase deficiency;Cervicothoracic spina bifida aperta;Upper thoracic spina bifida aperta;Lumbosacral spina bifida aperta;Thoracolumbosacral spina bifida aperta;Methotrexate toxicity or dose selection;Cervical spina bifida cystica;Non rare thrombophilia;Upper thoracic spina bifida cystica;Total spina bifida aperta;Total spina bifida cystica;Isolated anencephaly/exencephaly;Cervical spina bifida aperta. The disease is caused by mutations affecting the gene represented in this entry.  Disease susceptibility is associated with variations affecting the gene represented in this entry.  Disease susceptibility is associated with variations affecting the gene represented in this entry.  Disease susceptibility is associated with variations affecting the gene represented in this entry.  

[[http://www.uniprot.org/uniprot/MTHR_HUMAN MTHR_HUMAN]] Catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine.<ref>PMID:25736335</ref>

[[Category: Human]]

[[Category: Arrowsmith, C]]

[[Category: Baumgartner, M]]

[[Category: Bezerra, G A]]

[[Category: Borkowska, O]]

[[Category: Bountra, C]]

[[Category: Burgess-Brown, N]]

[[Category: Chalk, R]]

[[Category: Delft, F Von]]

[[Category: Edwards, A]]

[[Category: Ellis, K]]

[[Category: Froese, D S]]

[[Category: Kopec, J]]

[[Category: Krojer, T]]

[[Category: Kupinska, K]]

[[Category: Oberholzer, A E]]

[[Category: Rembeza, E]]

[[Category: Structural genomic]]

[[Category: Sorrell, F J]]

[[Category: Yue, W W]]

[[Category: Sgc]]