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==Crystal structure of the human tyrosine receptor phosphate gamma in complex with vanadate==
==Crystal structure of the human tyrosine receptor phosphate gamma in complex with vanadate==
<StructureSection load='2hy3' size='340' side='right' caption='[[2hy3]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='2hy3' size='340' side='right'caption='[[2hy3]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2hy3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HY3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HY3 FirstGlance]. <br>
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HY3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HY3 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=VO4:VANADATE+ION'>VO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=VO4:VANADATE+ION'>VO4</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PTPRG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hy3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hy3 OCA], [https://pdbe.org/2hy3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hy3 RCSB], [https://www.ebi.ac.uk/pdbsum/2hy3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hy3 ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/2hy3 TOPSAN]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hy3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hy3 OCA], [http://pdbe.org/2hy3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2hy3 RCSB], [http://www.ebi.ac.uk/pdbsum/2hy3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2hy3 ProSAT], [http://www.topsan.org/Proteins/NYSGXRC/2hy3 TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/PTPRG_HUMAN PTPRG_HUMAN]] Possesses tyrosine phosphatase activity.<ref>PMID:19167335</ref> 
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hy/2hy3_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hy/2hy3_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
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==See Also==
==See Also==
*[[Tyrosine phosphatase|Tyrosine phosphatase]]
*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Protein-tyrosine-phosphatase]]
[[Category: Bera A]]
[[Category: Bera, A]]
[[Category: Burley SK]]
[[Category: Burley, S K]]
[[Category: Freeman JC]]
[[Category: Freeman, J C]]
[[Category: Jin X]]
[[Category: Jin, X]]
[[Category: Min T]]
[[Category: Min, T]]
[[Category: Mu H]]
[[Category: Mu, H]]
[[Category: Reyes C]]
[[Category: Structural genomic]]
[[Category: Sauder JM]]
[[Category: Reyes, C]]
[[Category: Shapiro L]]
[[Category: Sauder, J M]]
[[Category: Smith D]]
[[Category: Shapiro, L]]
[[Category: Wasserman SR]]
[[Category: Smith, D]]
[[Category: Wasserman, S R]]
[[Category: Hydrolase]]
[[Category: NYSGXRC, New York SGX Research Center for Structural Genomics]]
[[Category: PSI, Protein structure initiative]]
[[Category: Twisted mixed beta-sheets flanked by {alpha}-helice]]

Latest revision as of 08:13, 13 August 2026

Crystal structure of the human tyrosine receptor phosphate gamma in complex with vanadate

2hy3, resolution 2.60Å

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