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==Crystal Structure of Plautia Stali Intestine Virus Intergenic Region Internal Ribosome Entry Site Ribosomal Binding Domain RNA at 3.1 Angstroms==
==Crystal Structure of Plautia Stali Intestine Virus Intergenic Region Internal Ribosome Entry Site Ribosomal Binding Domain RNA at 3.1 Angstroms==
<StructureSection load='2il9' size='340' side='right' caption='[[2il9]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
<StructureSection load='2il9' size='340' side='right'caption='[[2il9]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2il9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IL9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IL9 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2il9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plautia_stali_intestine_virus Plautia stali intestine virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IL9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IL9 FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2il9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2il9 OCA], [http://pdbe.org/2il9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2il9 RCSB], [http://www.ebi.ac.uk/pdbsum/2il9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2il9 ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2il9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2il9 OCA], [https://pdbe.org/2il9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2il9 RCSB], [https://www.ebi.ac.uk/pdbsum/2il9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2il9 ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Canonical cap-dependent translation initiation requires a large number of protein factors that act in a stepwise assembly process. In contrast, internal ribosomal entry sites (IRESs) are cis-acting RNAs that in some cases completely supplant these factors by recruiting and activating the ribosome using a single structured RNA. Here we present the crystal structures of the ribosome-binding domain from a Dicistroviridae intergenic region IRES at 3.1 angstrom resolution, providing a view of the prefolded architecture of an all-RNA translation initiation apparatus. Docking of the structure into cryo-electron microscopy reconstructions of an IRES-ribosome complex suggests a model for ribosome manipulation by a dynamic IRES RNA.
Structural basis for ribosome recruitment and manipulation by a viral IRES RNA.,Pfingsten JS, Costantino DA, Kieft JS Science. 2006 Dec 1;314(5804):1450-4. Epub 2006 Nov 23. PMID:17124290<ref>PMID:17124290</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2il9" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Costantino, D A]]
[[Category: Large Structures]]
[[Category: Kieft, J S]]
[[Category: Plautia stali intestine virus]]
[[Category: Pfingsten, J S]]
[[Category: Costantino DA]]
[[Category: Double-nested pseudoknot]]
[[Category: Kieft JS]]
[[Category: Ire]]
[[Category: Pfingsten JS]]
[[Category: Psiv]]
[[Category: Ribosomal binding domain]]
[[Category: Rna]]
[[Category: Under wound helix]]
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