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==Cryo-EM structure of the mitochondrial calcium uniporter from N. fischeri at 3.8 Angstrom resolution==
==Cryo-EM structure of the mitochondrial calcium uniporter from N. fischeri at 3.8 Angstrom resolution==
<StructureSection load='6d7w' size='340' side='right' caption='[[6d7w]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
<SX load='6d7w' size='340' side='right' viewer='molstar' caption='[[6d7w]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6d7w]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D7W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6D7W FirstGlance]. <br>
<table><tr><td colspan='2'>[[6d7w]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_fischeri Aspergillus fischeri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D7W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6D7W FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.8&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6d80|6d80]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6d7w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d7w OCA], [http://pdbe.org/6d7w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6d7w RCSB], [http://www.ebi.ac.uk/pdbsum/6d7w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6d7w ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6d7w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d7w OCA], [https://pdbe.org/6d7w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6d7w RCSB], [https://www.ebi.ac.uk/pdbsum/6d7w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6d7w ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MCU_NEOFI MCU_NEOFI] Highly selective calcium channel localized to the inner mitochondrial membrane, which mediates calcium uptake into the mitochondrial matrix (PubMed:29995855). Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates ATP production, cytoplasmic calcium signals and activation of cell death pathways (PubMed:29995855). Sufficient to operate as a pore-forming channel without the need of calcium-sensor or auxiliary subunit (PubMed:29995855).<ref>PMID:29995855</ref>
==See Also==
*[[Mitochondrial calcium uniporter|Mitochondrial calcium uniporter]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</SX>
[[Category: Armache, J P]]
[[Category: Aspergillus fischeri]]
[[Category: Bai, X C]]
[[Category: Large Structures]]
[[Category: Cheng, Y]]
[[Category: Armache J-P]]
[[Category: Nguyen, N X]]
[[Category: Bai XC]]
[[Category: Calcium channel]]
[[Category: Cheng Y]]
[[Category: Mitochondria]]
[[Category: Nguyen NX]]
[[Category: Transport protein]]
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