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==Structure and Dynamics of Human Apolipoprotein C-III==
==Structure and Dynamics of Human Apolipoprotein C-III==
<StructureSection load='2jq3' size='340' side='right' caption='[[2jq3]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
<StructureSection load='2jq3' size='340' side='right'caption='[[2jq3]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2jq3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JQ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JQ3 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2jq3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JQ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JQ3 FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">APOC3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jq3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jq3 OCA], [http://pdbe.org/2jq3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jq3 RCSB], [http://www.ebi.ac.uk/pdbsum/2jq3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jq3 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jq3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jq3 OCA], [https://pdbe.org/2jq3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jq3 RCSB], [https://www.ebi.ac.uk/pdbsum/2jq3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jq3 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/APOC3_HUMAN APOC3_HUMAN]] Defects in APOC3 are the cause of hyperalphalipoproteinemia type 2 (HALP2) [MIM:[http://omim.org/entry/614028 614028]]. HALP2 is a condition characterized by high levels of high density lipoprotein (HDL) and increased HDL cholesterol levels.<ref>PMID:2022742</ref>
[https://www.uniprot.org/uniprot/APOC3_HUMAN APOC3_HUMAN] Defects in APOC3 are the cause of hyperalphalipoproteinemia type 2 (HALP2) [MIM:[https://omim.org/entry/614028 614028]. HALP2 is a condition characterized by high levels of high density lipoprotein (HDL) and increased HDL cholesterol levels.<ref>PMID:2022742</ref>  
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/APOC3_HUMAN APOC3_HUMAN]] Inhibits lipoprotein lipase and hepatic lipase and decreases the uptake of lymph chylomicrons by hepatic cells. This suggests that it delays the catabolism of triglyceride-rich particles.  
[https://www.uniprot.org/uniprot/APOC3_HUMAN APOC3_HUMAN] Inhibits lipoprotein lipase and hepatic lipase and decreases the uptake of lymph chylomicrons by hepatic cells. This suggests that it delays the catabolism of triglyceride-rich particles.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Gangabadage, C S]]
[[Category: Large Structures]]
[[Category: Nilsson, S]]
[[Category: Gangabadage CS]]
[[Category: Olivecrona, G]]
[[Category: Nilsson S]]
[[Category: Tessari, M]]
[[Category: Olivecrona G]]
[[Category: Wijmenga, S]]
[[Category: Tessari M]]
[[Category: Zdunek, J]]
[[Category: Wijmenga S]]
[[Category: Apociii]]
[[Category: Zdunek J]]
[[Category: Apolipoprotein]]
[[Category: Dynamic]]
[[Category: Lipid binding protein]]
[[Category: Receptor]]
Retrieved from "https://proteopedia.org/2jq3"