6e29: Difference between revisions
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New page: '''Unreleased structure''' The entry 6e29 is ON HOLD Authors: Joshi, M., Yang, Y., Brunzelle, J.S., Couture, J.F. Description: Crystal structure of Myceliophteria_thermophila Cps50 (Sw... |
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The | ==Crystal structure of Myceliophteria_thermophila Cps50 (Swd1) beta-propeller domain== | ||
<StructureSection load='6e29' size='340' side='right'caption='[[6e29]], [[Resolution|resolution]] 1.82Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6e29]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermothelomyces_thermophilus Thermothelomyces thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E29 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6E29 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.818Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6e29 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e29 OCA], [https://pdbe.org/6e29 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6e29 RCSB], [https://www.ebi.ac.uk/pdbsum/6e29 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6e29 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/G2Q1Q9_MYCTT G2Q1Q9_MYCTT] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The methylation of histone 3 lysine 4 (H3K4) is carried out by an evolutionarily conserved family of methyltransferases referred to as complex of proteins associated with Set1 (COMPASS). The activity of the catalytic SET domain (su(var)3-9, enhancer-of-zeste, and trithorax) is endowed through forming a complex with a set of core proteins that are widely shared from yeast to humans. We obtained cryo-electron microscopy (cryo-EM) maps of the yeast Set1/COMPASS core complex at overall 4.0- to 4.4-A resolution, providing insights into its structural organization and conformational dynamics. The Cps50 C-terminal tail weaves within the complex to provide a central scaffold for assembly. The SET domain, snugly positioned at the junction of the Y-shaped complex, is extensively contacted by Cps60 (Bre2), Cps50 (Swd1), and Cps30 (Swd3). The mobile SET-I motif of the SET domain is engaged by Cps30, explaining its key role in COMPASS catalytic activity toward higher H3K4 methylation states. | |||
Structure and Conformational Dynamics of a COMPASS Histone H3K4 Methyltransferase Complex.,Qu Q, Takahashi YH, Yang Y, Hu H, Zhang Y, Brunzelle JS, Couture JF, Shilatifard A, Skiniotis G Cell. 2018 Aug 23;174(5):1117-1126.e12. doi: 10.1016/j.cell.2018.07.020. Epub, 2018 Aug 9. PMID:30100186<ref>PMID:30100186</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: | <div class="pdbe-citations 6e29" style="background-color:#fffaf0;"></div> | ||
[[Category: Brunzelle | == References == | ||
[[Category: Couture | <references/> | ||
[[Category: Joshi | __TOC__ | ||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Thermothelomyces thermophilus]] | |||
[[Category: Brunzelle JS]] | |||
[[Category: Couture JF]] | |||
[[Category: Joshi M]] | |||
[[Category: Yang Y]] | |||
Latest revision as of 06:17, 11 October 2023
Crystal structure of Myceliophteria_thermophila Cps50 (Swd1) beta-propeller domain
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