6e2j: Difference between revisions
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The entry | ==Crystal structure of the heterocomplex between human keratin 1 coil 1B containing S233L mutation and wild-type human keratin 10 coil 1B== | ||
<StructureSection load='6e2j' size='340' side='right'caption='[[6e2j]], [[Resolution|resolution]] 2.39Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6e2j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E2J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6E2J FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.386Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6e2j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e2j OCA], [https://pdbe.org/6e2j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6e2j RCSB], [https://www.ebi.ac.uk/pdbsum/6e2j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6e2j ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/K2C1_HUMAN K2C1_HUMAN] Epidermolytic palmoplantar keratoderma;Ichthyosis hystrix of Curth-Macklin;Annular epidermolytic ichthyosis;Epidermolytic ichthyosis;Keratosis palmoplantaris striata. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/K2C1_HUMAN K2C1_HUMAN] May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK.<ref>PMID:17956333</ref> <ref>PMID:21544310</ref> | |||
==See Also== | |||
*[[Keratins|Keratins]] | |||
== References == | |||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: Eldirany | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | |||
[[Category: Bunick CG]] | |||
[[Category: Eldirany SA]] | |||
[[Category: Lomakin IB]] | |||
Latest revision as of 14:38, 13 March 2024
Crystal structure of the heterocomplex between human keratin 1 coil 1B containing S233L mutation and wild-type human keratin 10 coil 1B
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